Clinicopathologic features of six cases of primary cervical lymphoma

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Stanford Cancer Center, Stanford University School of Medicine, Stanford, CA, USA.
American Journal of Obstetrics and Gynecology (Impact Factor: 4.7). 10/2005; 193(3 Pt 1):866-72. DOI: 10.1016/j.ajog.2005.04.044
Source: PubMed


Primary lymphoma of the uterine cervix is rare, with less than 60 cases reported. We present a series of 6 patients with cervical lymphoma and review the literature.
Between 1988 and 2003, we identified 6 women with primary lymphoma of the uterine cervix treated at our institutions. Data for analysis were obtained from hospital charts, office records, and tumor registry files. We also reviewed 20 published reports on cervical lymphoma, providing information on 58 additional patients.
The median age at diagnosis was 52 years (range 40-76). Three patients had an abnormal Papanicolaou test within 6 months of the diagnosis. Mean tumor size was 8.3 cm (range 3-14 cm). On the basis of the Ann Arbor system of staging where "E" denotes extranodal tumor origin, 2 patients had stage IE, 1 had stage IIIE, and 3 had stage IVE disease. The median follow-up for these 6 women was 33 months (range 12-120). Adding the 6 patients in our series to the 58 patients obtained from published reports, 43 had stage IE, 14 had stage IIE, 2 had stage IIIE, and 5 had stage IVE disease. There was no consistent pattern of treatment identified from our literature review.
Primary lymphoma of the uterine cervix is a rare malignancy. Most patients present with stage IE disease. Women with localized disease typically respond to various combinations of surgery, chemotherapy, and radiotherapy. Combination chemotherapy with tailored radiotherapy appears to be the preferred treatment option in women with advanced disease.

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    • "Most patients present at a mean age of 46 with vaginal bleeding, a large, bulky cervix on exam, and without the common B symptoms of lymphoma. Cervical cytology is not always helpful as the disease originates from the cervical stroma (Chan et al., 2005). Approximately 70% are diagnosed at Ann Arbor stage I, 22% at stage II, and 8% stage III and above. "
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    ABSTRACT: •Diffuse large B cell lymphoma of the cervix is a very rare gynecologic malignancy and difficult to diagnose.•This case is the youngest reported occurrence of cervical DLBCL with interesting considerations of GI involvement and fertility.
    Preview · Article · Dec 2014
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    • "Primary extranodal cervical NHL has a rapid growth pattern. Chan et al. [5] reviewed a series of 6 cases which all presented with a cervical lesion 6 cm or greater with a normal pelvic examination within the past year. Muntz et al. [6] reviewed a series of cervical NHL stage IE in which half of the patients had a tumor size more than 4 cm at presentation. "
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    ABSTRACT: Rare cervical cancers are responsible for a minority of cases encountered by a clinician. However, behavioral patterns, management, and prognosis of certain rare cervical cancers differ from either squamous carcinomas or adenocarcinomas. Here we present a case of a locally advanced cervical tumor as a presentation of an extranodal cervical non-Hodgkin lymphoma (NHL), with a review of the current literature.
    Full-text · Article · Mar 2014
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    • "In at least one study, surgery alone was reported to be useful in curing localized lymphoma of cervix (Chorlton et al., 1974), although other studies have found surgery less useful. Chan et al. reported that one of 6 cases of cervical lymphomas who had a previous subtotal hysterectomy for leiomyoma subsequently underwent trachelectomy with pelvic node dissection, and three months after primary surgery for her lymphoma, she experienced an intra-abdominal recurrence (Chan et al., 2005). Perren et al. also suggested that radical surgery offered no advantage in such cases on the basis of reviewed literature (Perren et al., 1992). "
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    ABSTRACT: Primary malignant lymphoma of the cervix is a rare disease. Because the number of reports of this cancer is limited, there is no consensus on its management, prognosis or the efficacy of various treatments. Primary malignant lymphoma of the cervix stage Ib was diagnosed in a 25-year-old woman. The patient was treated with 6 courses of CHOP chemotherapy (cyclophosphamide, doxorubicin, vincristine, and prednisone). Clinical and pathological responses were complete. This case supports current thinking in that, in selected young patients with primary malignant lymphoma of the cervix who desire to preserve fertility and ovarian functions, combination chemotherapy regimens such as CHOP are the treatment of choice.
    Full-text · Article · Jan 2001 · Asian Pacific journal of cancer prevention: APJCP
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