Wang TJ, Vasan RS. Epidemiology of uncontrolled hypertension in the United States

ArticleinCirculation 112(11):1651-62 · October 2005with50 Reads
DOI: 10.1161/CIRCULATIONAHA.104.490599 · Source: PubMed
    • "To our knowledge , this is the second French monocentric retrospective study conducted in young patients that tries to define the proportion of secondary versus essential hypertension, and to determine the characteristics and aetiologies of hypertension in this very specific population referred to an excellence center [7]. Epidemiological data collected from the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2012 showed an age-related increase in the prevalence of hypertension without any significant difference between genders [3,11]. Even if the prevalence of hypertension in the young population was rare, the analysis of NHANES register showed that younger patients were more prone to neglect their hypertension since only 60% were aware of this problem, only 47% were observant, and only 35% reached the objective of blood pressure control [3]. "
    [Show abstract] [Hide abstract] ABSTRACT: Objective: To study the prevalence of different causes of hypertension in young adults referred to a hypertension center in the south west of France. Methods: We conducted a retrospective overview of patients younger than 40years old hospitalized consecutively in the Hypertension department of Toulouse University Hospital between 2012 and 2014. Clinical data about gender, age, anthropomorphic parameters and blood pressure measurement by 24h Ambulatory Blood Pressure Monitoring (ABPM) were recorded. Biological data concerned dosages of kalemia, renin and aldosterone in the supine or after 15min of seating. Recorded radiological examinations were renal artery ultrasound and abdominal CT scan. Results: One hundred and forty-eight detailed medical records were analyzed, 69 women and 79 men. Among the 69 women, the causes of secondary hypertension were primary aldosteronism (n=7), fibromuscular dysplasia (n=5) and renal disease (n=4). Oral contraceptives were involved in 13 women. In addition, essential hypertension concerned 40 women (58%). Among the 79 men, the causes of secondary hypertension were primary aldosteronism (n=10), fibromuscular dysplasia (n=3), left main renal artery entrapment by a diaphragmatic crura (n=2), renal disease (n=1), pheochromocytoma (n=3) and coarctation of the aorta (n=2). In addition, essential hypertension concerned 58 men (73%). Conclusions: In our population, the prevalence of secondary hypertension is close to 33% (42% of females and 27% of males), with the following main causes: primary aldosteronism for 11.5%; fibromuscular dysplasia for 5.4%. Oral contraceptives were involved in the hypertension of 19% of the females.
    Full-text · Article · May 2016
    C. NoilhanC. NoilhanM. BarigouM. BarigouL. BielerL. Bieler+1more author...[...]
    • " nonfatal cardiovascular issues. [14,15] Women and older adults in Africa are mostly affected by HTN and overweight or obese patients or those with family history of high BP, diabetes, or pre‑HTN are also prone to high risk of HTN. [16,17] Diabetic patients may be prone to 1.5 to 3 times higher rate of prevalence of HTN than those without diabetes. [18] As per the JNC VIII guidelines, the target BP that needs to be attained is 140/90 mmHg. HTN associated with cardiovascular disorders is the leading cause of death rates in United States Population. [19]"
    Full-text · Dataset · Feb 2016 · Annales de cardiologie et d'angeiologie
    • "Therefore, further basic research is of paramount importance to uncover the genetic and biological mechanisms mediating potential gender differences in hypertension. EHT is a typical complex disease [28], with dozens of risk factors, such as obesity, physical inactivity, high-fat diet, cigarette smoking, alcohol abuse, excessive salt intake, and mental stress293031 . Growing evidence indicates that interactions among multiple genes and environmental factors may increase the susceptibility to EHT [32]. "
    [Show abstract] [Hide abstract] ABSTRACT: Previous genome-wide association studies (GWASs) found that several ATP2B1 variants are associated with essential hypertension (EHT). But the “genome-wide significant” ATP2B1 SNPs (rs2681472, rs2681492, rs17249754, and rs1105378) are in strong linkage disequilibrium (LD) and are located in the same LD block in Chinese populations. We asked whether there are other SNPs within the ATP2B1 gene associated with susceptibility to EHT in the Han Chinese population. Therefore, we performed a case-control study to investigate the association of seven tagSNPs within the ATP2B1 gene and EHT in the Han Chinese population, and we then analyzed the interaction among different SNPs and nongenetic risk factors for EHT. A total of 902 essential hypertensive cases and 902 normotensive controls were involved in the study. All 7 tagSNPs within the ATP2B1 gene were retrieved from HapMap, and genotyping was performed using the Tm-shift genotyping method. Chi-squared test, logistic regression, and propensity score analysis showed that rs17249754 was associated with EHT, particularly in females. The MDR analysis demonstrated that the interaction of rs2070759, rs17249754, TC, TG, and BMI increased the susceptibility to hypertension. Crossover analysis and stratified analysis indicated that BMI has a major effect on the development of hypertension, while ATP2B1 variants have a minor effect.
    Full-text · Article · Jan 2016
    Jin XuJin XuHai-xia QianHai-xia QianSu-pei HuSu-pei Hu+1more author...[...]
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