[Expression of urotensin II and G-protein coupled receptor 14 mRNA in human pheochromocytoma tissues].

ArticleinZhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 27(4):457-60 · August 2005with24 Reads
Source: PubMed

    Abstract

    To investigate the expression of urotensin II (U II) and G-protein coupled receptor 14 (GPR14) mRNA in human pheochromocytoma tissues.
    Total RNA from normal adrenal and pheochromocytoma tissues was extracted. The reverse transcription-polymerase chain reaction method was used to evaluate the levels of U II and GPR14 mRNA expression in human pheochromocytoma tissues.
    There was no significant difference of U II and GPR14 mRNA expression between normal adrenal cortex and medulla. The expression of U II and GPR14 mRNA in pheochromocytoma was significantly lower than that in normal adrenal cortex and medulla (P < 0.05). The expression of GPR14 mRNA in adrenal pheochromocytomas was significantly lower than that of extra-adrenal pheochromocytomas (P < 0.05).
    U II and GPR14 may play a role in the pathogenesis and hypertension regulating of pheochromocytoma.