Decreased -Cell Function in Overweight Latino Children With Impaired Fasting Glucose

Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA.
Diabetes Care (Impact Factor: 8.42). 11/2005; 28(10):2519-24. DOI: 10.2337/diacare.28.10.2519
Source: PubMed


To determine whether overweight Latino children with impaired fasting glucose (IFG) (> or = 100 mg/dl) have increased insulin resistance or decreased beta-cell function compared with those with normal fasting glucose (NFG).
We studied 207 healthy overweight Latino children, aged 8-13 years, with a family history of type 2 diabetes. Fasting and 2-h glucose and insulin were assessed by oral glucose tolerance test. Insulin sensitivity (S(i)), the acute insulin response to glucose (AIRg), and the disposition index (DI; an index of beta-cell function) were determined using the insulin-modified intravenous glucose tolerance test and minimal modeling. Body composition was determined by dual-energy X-ray absorptiometry.
There were no differences in body composition between NFG (n = 182) and IFG (n = 25) children. Compared with children with NFG, children with IFG had higher fasting and 2-h glucose values and higher fasting insulin. After adjusting for covariates, children with IFG had no difference in S(i) but 15% lower DI than NFG children (2,224 +/- 210 vs. 2,613 +/- 76, P < 0.05). Multivariate linear regression showed that AIRg and DI, but not S(i), were significant predictors of fasting blood glucose.
In overweight Latino adolescents with a family history of type 2 diabetes, IFG is associated with impaired beta-cell function and therefore may identify children likely to be at risk for progression to type 2 diabetes. The actual risk of progression of IFG to type 2 diabetes remains to be determined by prospective longitudinal studies.

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Available from: Geoff Ball, Sep 22, 2015
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    • "Saliva samples were processed immediately by centrifuging at 2500 rpm for 10 minutes and frozen at -70°C until assayed. Fasting blood was drawn to assess morning serum cortisol, followed by a 3-hour insulin-modified, frequently-sampled intravenous glucose tolerance test (FSIVGTT), as previously described [5]. "
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