How Themistocles Zammit found Malta Fever (brucellosis) to be transmitted by the milk of goats

School of Philosophy, University of Leeds, Leeds LS2 9HD, UK.
Journal of the Royal Society of Medicine (Impact Factor: 2.12). 11/2005; 98(10):451-4. DOI: 10.1258/jrsm.98.10.451
Source: PubMed
Download full-text


Available from: Harold V Wyatt
  • Source
    • "As in other infectious disease, lower genetic diversity and crowded effect may favor transmission and select for faster replicating organisms with major zoonotic potential (McDaniel et al., 2013). Examples of these were observed in the early days of brucellosis in Malta (Wyatt, 2005, 2009a), and more recently in foodborne outbreaks in Peru (Román et al., 2013) and massive outbreaks in Inner Mongolia, threatening hundreds of thousands of people. "
    [Show abstract] [Hide abstract]
    ABSTRACT: Members of the genus Brucella are pathogenic bacteria exceedingly well adapted to their hosts. The bacterium is transmitted by direct contact within the same host species or accidentally to secondary hosts, such as humans. Human brucellosis is strongly linked to the management of domesticated animals and ingestion of their products. Since the domestication of ungulates and dogs in the Fertile Crescent and Asia in 12000 and 33000 ya, respectively, a steady supply of well adapted emergent Brucella pathogens causing zoonotic disease has been provided. Likewise, anthropogenic modification of wild life may have also impacted host susceptibility and Brucella selection. Domestication and human influence on wild life animals are not neutral phenomena. Consequently, Brucella organisms have followed their hosts' fate and have been selected under conditions that favor high transmission rate. The "arm race" between Brucella and their preferred hosts has been driven by genetic adaptation of the bacterium confronted with the evolving immune defenses of the host. Management conditions, such as clustering, selection, culling, and vaccination of Brucella preferred hosts have profound influences in the outcome of brucellosis and in the selection of Brucella organisms. Countries that have controlled brucellosis systematically used reliable smooth live vaccines, consistent immunization protocols, adequate diagnostic tests, broad vaccination coverage and sustained removal of the infected animals. To ignore and misuse tools and strategies already available for the control of brucellosis may promote the emergence of new Brucella variants. The unrestricted use of low-efficacy vaccines may promote a "false sense of security" and works towards selection of Brucella with higher virulence and transmission potential.
    Full-text · Article · May 2014 · Frontiers in Microbiology
  • Source

    Preview · Article ·
  • Source

    Full-text · Article · Mar 2006 · Journal of the Royal Society of Medicine
Show more