Peptide YY Is a Regulator of Energy Homeostasis in Obese Children before and after Weight Loss

University of Bonn, Bonn, North Rhine-Westphalia, Germany
Journal of Clinical Endocrinology & Metabolism (Impact Factor: 6.21). 12/2005; 90(12):6386-91. DOI: 10.1210/jc.2005-1357
Source: PubMed


The gut hormone peptide YY(3-36) (PYY) reduces food intake via hypothalamic Y2 receptors in the brain. There is not much known about PYY in obese children.
The objective of this study was to investigate the role of PYY in the metabolic changes in obese children and its change during weight loss.
The study was performed at a university medical center.
We studied 73 obese children and 45 age-matched normal-weight children.
We determined fasting serum total PYY and leptin by RIA in obese and normal-weight children. Fasting PYY was also measured in 28 obese children before and after completion of a 1-yr outpatient weight reduction program.
PYY, insulin, and body mass index were the main outcome measures.
Obese children demonstrated significantly lower PYY levels than lean children (median, 67 vs. 124 pg/ml; P < 0.001). Fasting PYY correlated negatively to the degree of overweight. PYY levels did not differ significantly between boys and girls, nor between prepubertal and pubertal children. The group of patients participating in the outpatient weight reduction program was divided into four quartiles according to their changes in body mass index SD score over a 1-yr period. PYY increased significantly in patients with the most effective weight loss, but decreased in the subgroup of children with weight gain.
PYY is negatively correlated to the degree of overweight, with reduced values in obese compared with normal-weight children. Decreased PYY levels could predispose subjects to develop obesity. Our results indicate that low pretreatment PYY levels that increase during weight loss may be a predictor of maintained weight loss.

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    • "However, Geliebter et al. found that obese women with BED, as compared to nonbinge eating controls, had lower levels of fasting ghrelin and significantly lower concentrations over time [14]. Inconsistent evidence to date on the effects of obesity on peptide YY (PYY), a satiety-signaling protein, underscores the need for further investigation in both adult and adolescent populations [15] [16] [17] [18]. In regard to binge eating, Geliebter et al. found no differences in PYY levels in a study of obese women with and without BED following a liquid mixed meal [19]. "
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    • "GLP-1 and PYY have been suggested to play an important role in weight management and the prevention of metabolic syndrome (Roth et al., 2005). In general, obese or sedentary individuals have lower concentrations of GLP-1 and PYY (Roth et al., 2005; Chanoine et al., 2008). Chronic exercise training significantly increases GLP-1 and PYY concentrations in fasting and postprandial states (Chanoine et al., 2008; Jones et al., 2009; Guelfi et al., 2013). "
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