"Lock-in" modified CycloSal nucleotides - The second generation of CycloSal prodrugs

ArticleinNucleosides Nucleotides & Nucleic Acids 24(5-7):939-42 · February 2005with11 Reads
Impact Factor: 1.02 · DOI: 10.1081/NCN-200059298 · Source: PubMed


    A new generation of cycloSal-pronucleotides is presented. CycloSal-d4TMPs have been modified by introduction of an esterase-cleavable site in order to trap them inside cells. Hydrolysis studies in different media (PBS, CEM/0- and liver extracts) and anti-HIV evaluation of separated diastereomers revealed unexpected differences between the isomers.