Heat Shock Protein HSP70 Increases the Resistance of Cortical Cells to Glutamate Excitotoxicity

ArticleinBulletin of Experimental Biology and Medicine 140(1):1-5 · August 2005with13 Reads
Impact Factor: 0.36 · DOI: 10.1007/s10517-005-0396-x · Source: PubMed

    Abstract

    Preincubation of cultured slices of the olfactory cortex of rat brain with heat shock protein in a concentration of 1 microg/ml protected the pre- and postsynaptic mechanisms of glutamatergic synaptic transmission from glutamate excitotoxicity (50 mM) inducing blockade of excitatory postsynaptic function and reducing presynaptic processes. It was hypothesized that heat shock protein protects AMPA and NMDA receptor-mediated processes.