APOE ε4 is not associated with Alzheimer's Disease in elderly Nigerians

Department of Pathology and Laboratory Medicine, Indiana University-Purdue University Indianapolis, Indianapolis, Indiana, United States
Annals of Neurology (Impact Factor: 9.98). 01/2006; 59(1):182-5. DOI: 10.1002/ana.20694
Source: PubMed


Since 1992, research teams from Indiana University and the University of Ibadan have been collecting and comparing data from two diverse, elderly populations to identify risk factors for dementia and Alzheimer's disease. Apolipoprotein E (APOE) was genotyped in 2,245 Nigerian samples. Of these, 830 had a diagnosis: 459 were normal, and 140 had dementia including 123 diagnosed with Alzheimer's disease. In contrast with other populations, the APOE epsilon4 allele was not significantly associated with Alzheimer's disease or dementia. This lack of association in the Yoruba might reflect genetic variation, environmental factors, as well as genetic/environmental interactions.


Available from: Sujuan Gao, Apr 11, 2014
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    • "Studies conducted in Nigeria, Kenya, Tanzania, and Benin all reported a high frequency of the APOE-ɛ4 allele (genetic risk factor for AD) in Africa [8, 9, 20, 25, 26, 39]. Despite the high frequency of the APOE-ɛ4 allele found in Africans, there was a general lack of association between the allele and dementia in the region [21, 25, 39]. Interestingly, Guerchet et al., in their Benin study, reported a significantly lower frequency of the APOE-ɛ2 allele in study participants with dementia [9]. "
    [Show abstract] [Hide abstract] ABSTRACT: Objectives. To review epidemiologic studies on the prevalence, incidence, and risk factors of dementia in sub-Saharan Africa (SSA). Methods. A MEDLINE search (from January 1992 to December 31, 2013) of epidemiologic studies, with no language restriction, was conducted using the keywords "dementia" or "Alzheimer's" and "Africa." We selected for review population and hospital-based studies that reported the prevalence, incidence, or risk factors of dementia in SSA in people aged 60 years and above. References of selected articles were reviewed to identify additional relevant articles that met our selection criteria. Results. Of a total of 522 articles, 41 were selected and reviewed. The reported prevalence of dementia in SSA varied widely (range: 2.29%-21.60%); Alzheimer's disease was the most prevalent type of dementia. Only two studies conducted in Nigeria reported incidence data. Major risk factors identified include older age, female gender, cardiovascular disease, and illiteracy. Conclusion. Data on the epidemiology of dementia in SSA is limited. While earlier studies reported a lower prevalence of dementia in older persons, recent studies have put these findings into question suggesting that dementia prevalence rates in SSA in fact parallel data from Western countries.
    Full-text · Article · Aug 2014 · International Journal of Alzheimer's Disease
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    • "In this study, the presence of depressive symptoms at the time of the survey was significantly associated with dementia. This factor has already been associated with cognitive impairment in another elderly African population [9]. The relationship between depression and dementia is discussed in the literature [41] [42] [43], but it remains controversial whether depressive symptoms represent a risk factor for dementia, or if they are an early symptom of neurodegeneration or a response to first cognitive deficit symptoms. "
    [Show abstract] [Hide abstract] ABSTRACT: Risk factors for dementia in American and European countries have been well investigated. However, little research has been carried out in sub-Saharan Africa, where life events as well as environmental, socio-economic, and modifiable risk factors (i.e., cardiovascular risk factors) may differ. Two cross-sectional surveys were conducted in representative samples of the older general population living in Bangui (Central African Republic) and Brazzaville (Congo). Dementia was defined according to the DSM-IV criteria. Multivariate regression analyses were performed in order to identify independent factors associated with dementia. Among the 977 elderly Africans included in this analysis, 75 (7.6%) were diagnosed as having dementia. Increasing age, female gender, hypertension, a body mass index <18.5 kg/m2, depressive symptoms, and the lack of a primary education were significantly associated with dementia. Among life events, the death of one parent during childhood and recently having moved house were also associated with dementia. Beyond the usual risk factors for dementia, this study highlights the role of stressful events in low-income countries. Factors associated with dementia in African countries seem different from established factors in high-income countries and require further investigation.
    Full-text · Article · Dec 2011 · Journal of Alzheimer's disease: JAD
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    • "However, in African-Americans, other populations of west African ancestry, and Hispanics the association of AD with e4 is relatively weak and inconsistent, even though the frequency of the risk-conferring APOE e4 allele is higher in those of African ancestry than in other continental groups [13]. No association of APOE genotype with AD has been observed in studies in Nigeria [14], or Kenya [15]. Two longitudinal studies in the US also suggest no association between APOE e4 and incident AD among African Americans, while the incidence of AD seemed to be higher for African Americans in every APOE genotype [3,4]. "
    [Show abstract] [Hide abstract] ABSTRACT: The prevalence and incidence of dementia are low in Nigeria, but high among African-Americans. In these populations there is a high frequency of the risk-conferring APOE-e4 allele, but the risk ratio is less than in Europeans. In an admixed population of older Cubans we explored the effects of ethnic identity and genetic admixture on APOE genotype, its association with dementia, and dementia prevalence. A cross-sectional catchment area survey of 2928 residents aged 65 and over, with a nested case-control study of individual admixture. Dementia diagnosis was established using 10/66 Dementia and DSM-IV criteria. APOE genotype was determined in 2520 participants, and genetic admixture in 235 dementia cases and 349 controls. Mean African admixture proportions were 5.8% for 'white', 28.6% for 'mixed' and 49.6% for 'black' ethnic identities. All three groups were substantially admixed with considerable overlap. African admixture was linearly related to number of APOE-e4 alleles. One or more APOE-e4 alleles was associated with dementia in 'white' and 'black' but not 'mixed' groups but neither this, nor the interaction between APOE-e4 and African admixture (PR 0.52, 95% CI 0.13-2.08) were statistically significant. Neither ethnic identity nor African admixture was associated with dementia prevalence when assessed separately. However, considering their joint effects African versus European admixture was independently associated with a higher prevalence, and 'mixed' or 'black' identity with a lower prevalence of dementia. APOE genotype is strongly associated with ancestry. Larger studies are needed to confirm whether the concentration of the high-risk allele in those with African ancestry is offset by an attenuation of its effect. Counter to our hypothesis, African admixture may be associated with higher risk of dementia. Although strongly correlated, effects of admixture and ethnic identity should be distinguished when assessing genetic and environmental contributions to disease risk in mixed ancestry populations.
    Full-text · Article · Mar 2011 · BMC Medical Genetics
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