Gene regulation profiles by progesterone and dexamethasone in human endometrial cancer Ishikawa H cells

Department of Biochemistry and Molecular Biology, University of New Mexico, Albuquerque, New Mexico, United States
Gynecologic Oncology (Impact Factor: 3.77). 05/2006; 101(1):62-70. DOI: 10.1016/j.ygyno.2005.09.054
Source: PubMed


Progesterone and glucocorticoids such as dexamethasone mediate distinct biological functions, yet they bind to receptors that recognize the same consensus DNA response element. In breast cancer, progestins are associated with the incidence and progression of tumors, whereas glucocorticoids are growth-suppressive in mammary cancer cells; the differential effects of these two steroids are less well understood in the hormone-dependent disease cancer of the uterine endometrium. We set out to identify genes that are regulated by progesterone through progesterone receptors and dexamethasone through glucocorticoid receptors in a well-differentiated human endometrial cancer cell line.

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