Nanoparticles of Biodegradable Polymers for New-Concept Chemotherapy

Department of Chemical and Biomolecular Engineering, Faculty of Engineering, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260.
Expert Review of Medical Devices (Impact Factor: 1.68). 10/2004; 1(1):115-25. DOI: 10.1586/17434440.1.1.115
Source: PubMed


The current regimen of chemotherapy is far from satisfactory--its efficiency is limited and patients suffer from serious side effects. Various drug delivery devices have been under intensive investigation in the past few decades in attempts to develop controlled and targeted methods of chemotherapy administration. This article reviews the latest developments in nanoparticles of biodegradable polymers for chemotherapy of cancer and other diseases such as cardiovascular restenosis. The preliminary results obtained in the author's laboratory are used to demonstrate the concept. This review is written with the belief that engineering, in particular, chemical engineering principles, can be applied and further developed to solve the problems in the current practice of chemotherapy and promote a new concept of chemotherapy - chemotherapy at home.

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    • "At present, anticancer drugs development is in demand because of the controlled release after their administration in the body to a better treatment and patient compliance. Stimuli reactive biodegradable polymeric nanoparticles have become the keen interest of scientists in recent years due to their fascinated delivery of the drugs in a controlled manner [16]. These stimuli reactive polymeric systems have established precise advantages in the treatment of world's life threatening diseases and also in the release of vaccines [17] [18]. "
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