Epidemiology of cerebral palsy

Telethon Institute for Child Health Research, Centre for Child Health Research, The University of Western Australia, P.O. Box 855, West Perth, WA 6872, Australia.
Seminars in Fetal and Neonatal Medicine (Impact Factor: 3.03). 05/2006; 11(2):117-25. DOI: 10.1016/j.siny.2005.10.010
Source: PubMed


The term cerebral palsy refers to a range of clinical symptoms, with related service requirements, resulting from lesions or abnormalities in the brain arising early in life. It is not a diagnosis; aetiology and pathology are variable. This article discusses the definition and differential classification of cerebral palsy, describes trends in its frequency over time stratified by associated variables, and briefly reviews the most recent findings concerning its aetiology. (c) 2005 Elsevier Ltd. All rights reserved.

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    • "The motor disorders of cerebral palsy are often accompanied by disturbances of sensation, perception, cognition, communication, and behavior, by epilepsy and by secondary musculoskeletal problems [1]. As one of the most common causes of physical disability in childhood, CP has an approximate prevalence of 1.5–3.6 per 1,000 individuals [2] [3]. Despite extensive treatment, neurological impairments still eventually lead CP patients to lifelong disability [4]. "
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    ABSTRACT: This retrospective study aimed to assess the safety of patients with severe cerebral palsy (CP), who received allogeneic umbilical cord blood stem cells (UCBSCs) treatment from August 2009 to December 2012 in Guangdong Provincial Hospital of Chinese Medicine. A total of 47 patients with average age of 5.85 ± 6.12 years were evaluated in this study. There was no significant association with allogeneic UCBSCs treatments found in the data of the laboratory index . No casualties occurred. Some adverse events during treatments were found in 26 (55.3%) patients, including fever (42.6%) and vomiting (21.2%). Intrathecal infusion and the ages at the initiation of treatment (≤10 years old) were risk factors for the occurrence of adverse events by logistic regression analysis. However, all adverse events disappeared after symptomatic treatment. No treatment related serious adverse events were found in follow-up visits within 6 months. In conclusion, allogeneic UCBSCs treatment was relatively safe for severe CP patients.
    Full-text · Article · May 2015 · Stem cell International
    • "It arises from a variety of causal pathways, or a combination of events leading to injury in the developing brain and motor impairment [1] , often with multiple comorbidities , such as intellectual disability [2]. The overall birth prevalence of CP has remained the same for 60 years, however, there have been recent reductions in the rates of CP among babies born extremely and very preterm [3,4]. Advances in antenatal and neonatal care, alongside novel neuro-protective and regenerative agents currently under investigation, offer great promise for reducing long-term cerebral impairments. "
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    ABSTRACT: Abstract Objective To systematically review meta-analyses (MAs) and randomised controlled trials (RCTs) of interventions for infants at risk of cerebral palsy (CP) to determine if consensus exists in study end-points. Methods MAs within the "Neonatal" and "Pregnancy and Childbirth" Review Groups in Cochrane Database of Systematic Reviews (to June 2011) were included if they contained risk factors for CP as a study end-point, and were either published in 2010 or 2011 or cited >20 times in Sciverse Scopus. Up to 20 RCTs from each MA were included. Outcome measures, definitions, and cut points for ordinal groupings were extracted from MAs and RCTs and frequencies calculated. Results Twenty-two MAs and 165 RCTs were appraised. High consistency existed in types of outcome domains listed as important in MAs. For 10/16 most frequently cited outcome domains, <50% of RCTs contributed data for meta-analyses. Low consistency in outcome definitions, measures, cut points in RCTs and long term follow-up prohibited data aggregation. Conclusions Variation in outcome measurement and long term follow up has hampered the ability of RCTs to contribute data on important outcomes for CP, resulting in lost opportunities to measure the impact of maternal and neonatal interventions. There is an urgent need for and long term follow up of these interventions and an agreed set of standardised and clinically relevant common data elements for study end-points.
    No preview · Article · Oct 2014 · Journal of Maternal-Fetal and Neonatal Medicine
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    • "The prevalence of CP worldwide is estimated at between 2 and 2.5 cases per 1,000 births, and although the above definition emphasizes the motor nature of the disorder, it also recognizes that in most cases the problems are accompanied by changes in other areas and may be more intense or problematic depending on the person or their developmental stage (Blair 2010; Bottcher 2010; Odding et al. 2006). The first critical situation encountered by parents of children with CP is usually linked to the often complex process of confirming and disclosing the diagnosis (Baird et al. 2000). "
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    ABSTRACT: The implications of caring for a child with cerebral palsy (CP) are considerable, and parents have to cope with many changing demands related to the specific needs of their child. A new research field, devoted to the consequences of these caring tasks, has recently emerged. However, an overall vision is lacking, one that would enable us to understand how research is evolving and the relevant data that should be taken into account when planning interventions with these families. In this paper, we review the literature on the effects of caregiving on parents of children with CP, and summarize the factors related to these effects. A systematic search of online databases was performed and further studies were identified based on the reference lists of selected articles. Forty six articles that met the inclusion criteria were analysed. The review shows that caregivers of children with CP tend to have high levels of stress and depression and lower quality of life than parents of healthy children. We identify child behaviour and cognitive problems, low caregiver self-efficacy and low social support as factors that are consistently related with higher levels of stress and depression. The implications of these findings are discussed, especially those related to interventions that should be addressed to the family as a whole and which should aim to enhance parents’ competence and resources to better cope with the demands of the caring task.
    Full-text · Article · Oct 2013 · Journal of Developmental and Physical Disabilities
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