Dysfunction of lamin A triggers a DNA damage response and cellular senescence

ArticleinDNA Repair 5(2):286-9 · March 2006with2 Reads
Impact Factor: 3.11 · DOI: 10.1016/j.dnarep.2005.10.007 · Source: PubMed

    Abstract

    In higher eukaryotes, the nuclear lamins play an important role in maintaining the integrity of the nuclear envelope and the nucleus itself. Two recent papers show that a mutation that affects the processing of one of the nuclear lamins, lamin A, results in increased sensitivity to DNA damaging agents, an elevated DNA damage response, and a senescent phenotype. These studies underscore the role of the nuclear envelope in maintaining genomic stability and the interplay between nuclear architecture and the DNA damage response.