Cytokinesis: Breaking the Ties That Bind

University of Massachusetts Medical School, Biotech 4, 377 Plantation Street, Worcester, Massachusetts 01605, USA.
Current Biology (Impact Factor: 9.57). 01/2006; 15(24):R998-1000. DOI: 10.1016/j.cub.2005.11.049
Source: PubMed


It has been unclear how cells complete cell division and resolve membrane connections to bring about cell separation. Recent work has shown that targeted secretion to the midbody is required to complete cell division.

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    • "Cleavage furrow ingression eventually creates a thin midbody that connects the dividing cells and the Flemming body forms at the center of the midbody. Some Flemming body components are present throughout furrow ingression, whereas others are delivered late, including cellular membranes, endocytic factors, and secretory vesicles and their associated fusion machinery (McCollum, 2005). "
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