Heart Transplantation for Progressive Cardiomyopathy as a Manifestation of MELAS Syndrome

ArticleinThe Journal of heart and lung transplantation: the official publication of the International Society for Heart Transplantation 24(12):2286-9 · January 2006with48 Reads
Impact Factor: 6.65 · DOI: 10.1016/j.healun.2005.05.012 · Source: PubMed

    Abstract

    Mitochondrial diseases represent a heterogeneous group of disorders associated with a wide array of clinical manifestations. The presentation of patients with mitochondrial pathology largely depends upon the dysfunction of organ systems with large metabolic/energy requirements, including cardiac, neurologic, and musculoskeletal. In particular, mitochondrial myocardial disease can be progressive resulting in congestive heart failure and end-stage heart disease. This article reviews the role of heart transplantation for a particular variant of mitochondrial disorder, mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome, and discusses perioperative management issues related to transplantation for mitochondrial cardiomyopathies.