Nasal glioma (neuroglial heterotopia) mimicking an astrocytoma: Case report

Department of Pathology, Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz, I.R. Iran.
Ear, nose, & throat journal (Impact Factor: 1). 11/2005; 84(10):657-8.
Source: PubMed


Nasal glioma is a rare benign tumor that usually occurs during infancy. We report a case of nasal glioma in a 6-month-old boy in which the histomorphologic features resembled those of an anaplastic astrocytoma.

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    ABSTRACT: Neuroglial heterotopias are rare congenital masses that are thought to represent encephaloceles that become sequestered on the extracranial side of the skull base. Although most often adjacent to bony skull base defects, they lack communication to the subarachnoid space. They contain mature neuroglial tissue and specialized central nervous system elements, such as a functioning choroid plexus. A case is presented of neonatal airway obstruction due to neuroglial heterotopia in the nasopharynx. The patient's clinical course and treatment are discussed, along with their radiology and histology. The relevant scientific literature is reviewed.
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    ABSTRACT: In this report, we describe an infant with a nasal tip glioma treated by excision via external rhinoplasty. A 3-month-old full-term, otherwise healthy infant presented with a slowly enlarging midline mass of the nasal tip. Clinically the mass appeared cystic without trans-illumination, enlargement with crying, or signs of infection. On successive CT scans at 3 and 5 months old the mass appeared as an enlarging focal prominence to the left of midline with central hypodensity without evidence for intracranial extension. Preoperatively the differential diagnosis included nasal dermoid, glioma, and hemangioma. The mass was removed at 6 months of age via an open rhinoplasty approach with conchal cartilage grafting to reconstruct the left upper lateral cartilage. The final pathological diagnosis was nasal glioma (glial heterotopia) with fibrosis. Pre-operative, intra-operative, and post-operative photos were taken. The patient has been followed up for 6 months without evidence of recurrence or other complications. A review of the literature on nasal glioma and external nasal surgery in infancy is presented.
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