Genetic variation in DTNBP1 influences general cognitive ability

Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, Albert Einstein College of Medicine, Glen Oaks, NY 11004, USA.
Human Molecular Genetics (Impact Factor: 6.39). 06/2006; 15(10):1563-8. DOI: 10.1093/hmg/ddi481
Source: PubMed


Human intelligence is a trait that is known to be significantly influenced by genetic factors, and recent linkage data provide
positional evidence to suggest that a region on chromosome 6p, previously associated with schizophrenia, may be linked to
variation in intelligence. The gene for dysbindin-1 (DTNBP1) is located at 6p and has also been implicated in schizophrenia, a neuropsychiatric disorder characterized by cognitive dysfunction.
We report an association between DTNBP1 genotype and general cognitive ability (g) in two independent cohorts, including 213 patients with schizophrenia or schizo-affective disorder and 126 healthy volunteers.
These data suggest that DTNBP1 genetic variation influences human intelligence.

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Available from: Raju Kucherlapati
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    • "Dysbindin has been implicated in cognitive performance in healthy (Luciano et al., 2009) and schizophrenia cases (Burdick et al., 2006; Fallgatter et al., 2006). Genetic variants of DTNBP1 have been associated with working memory (Donohoe et al., 2007), IQ (Zinkstok et al., 2007; Fatjovilas et al., 2011) and execution function (Luciano et al., 2009; Fatjovilas et al., 2011). "
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    • "Recent studies have made significant progress in identifying genes correlated with greater intelligence. (see, e.g., [41–44]) Based on such findings parents may, in the near future, be able to use genetic manipulation to improve people’s cognitive capacities—which, given the above arguments, would lead to enhancement of autonomy. Of course, genetic manipulation is not the only way to enhance autonomy; other biomedical interventions such as pharmaceuticals, or more traditional means such as education, could have the effect. "
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    • "Genetic variations in the DTNBP1 gene have been associated with alterations in human behavior and especially in cognitive abilities (Burdick et al., 2006; Fallgatter et al., 2006; Hashimoto et al., 2009; Luciano et al., 2009; Markov et al., 2009; Thimm et al., 2010; Wolf et al., 2011). In particular, single-nucleotide polymorphisms (SNPs) in the DTNBP1 gene in schizophrenia have been associated with (i) greater decline in general cognitive ability from a premorbid to a clinical state (Burdick et al., 2007), (ii) lower general cognitive ability (Burdick et al., 2006), (iii) lower scores on verbal performance and full-scale IQ tests (Zinkstok et al., 2007), and (iv) deficits on a spatial working memory task and on a go–no-go attentional response task (Donohoe et al., 2007). Moreover, patients with schizophrenia carrying a high-risk DTNBP1 haplotype are more likely to display high levels of negative symptoms (Fanous et al., 2005). "
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