Article

Mobile phone use and risk of glioma in adults: a UK case-control study

The University of Manchester, Manchester, England, United Kingdom
BMJ (online) (Impact Factor: 17.45). 05/2006; 332(7546):883-7. DOI: 10.1136/bmj.38720.687975.55
Source: PubMed

ABSTRACT

To investigate the risk of glioma in adults in relation to mobile phone use.
Population based case-control study with collection of personal interview data.
Five areas of the United Kingdom.
966 people aged 18 to 69 years diagnosed with a glioma from 1 December 2000 to 29 February 2004 and 1716 controls randomly selected from general practitioner lists.
Odds ratios for risk of glioma in relation to mobile phone use.
The overall odds ratio for regular phone use was 0.94 (95% confidence interval 0.78 to 1.13). There was no relation for risk of glioma and time since first use, lifetime years of use, and cumulative number of calls and hours of use. A significant excess risk for reported phone use ipsilateral to the tumour (1.24, 1.02 to 1.52) was paralleled by a significant reduction in risk (0.75, 0.61 to 0.93) for contralateral use.
Use of a mobile phone, either in the short or medium term, is not associated with an increased risk of glioma. This is consistent with most but not all published studies. The complementary positive and negative risks associated with ipsilateral and contralateral use of the phone in relation to the side of the tumour might be due to recall bias.

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    • "In low grade gliomas, although mobile phone use has been associated with increased risk, when focusing on survival, a survival benefit was reported in low grade glioma patients with mobile phone use. The authors hypothesis was that tumor volume was larger in exposed than in unexposed patients, which would permit an earlier diagnosis and surgicalintervention[30]. In 2010 Hardell et al reported an increased risk for glioma for both short and long term mobile phone users. "
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    ABSTRACT: Mobile phone use has been discussed over the last few decades with increased risk for intracranial tumors. The majority of studies have been conducted on gliomas and meningiomas. Although some case-control studies have found a positive association between the use of mobile phones and the risk of tumors, other studies have reported no significant association. A possible long-term mobile phone use may lead to increased risk however, the evidences are not yet conclusive and further studies are needed. In the present study we reviewed the current evidence for the association between mobile phone use and risk for intracranial tumors.
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    • "Although it is agreed that tumorigenesis is linked to physical stress and environmental alterations, the nature or existence of carcinogenic effects related to EMF exposure have remained unclear12345. To date, most epidemiological studies have not demonstrated an increased risk of brain tumor development with overall mobile phone usage6789. However, some positive associations have been reported, such as a relationship between an increased risk of acoustic neuroma and long-term mobile phone use[10,11]. "
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    ABSTRACT: Background: The increase in mobile phone use has generated concerns about possible risks to human health, especially the development of brain tumors. Whether tumor patients should continue to use mobile telephones has remained unclear because of a paucity of information. Herein, we investigated whether electromagnetic fields from mobile phones could alter the biological features of human tumor cells and act as a tumor-promoting agent. Methods: Human glioblastoma cell lines, U251-MG and U87-MG, were exposed to 1950-MHz time division-synchronous code division multiple access (TD-SCDMA) at a specific absorption rate (maximum SAR = 5.0 W/kg) for 12, 24, and 48 h. Cell morphologies and ultra-structures were observed by microscopy and the rates of apoptosis and cell cycle progression were monitored by flow cytometry. Additionally, cell growth was determined using the CKK-8 assay, and the expression levels of tumor and apoptosis-related genes and proteins were analyzed by real-time PCR and western blotting, respectively. Tumor formation and invasiveness were measured using a tumorigenicity assay in vivo and migration assays in vitro. Results: No significant differences in either biological features or tumor formation ability were observed between unexposed and exposed glioblastoma cells. Our data showed that exposure to 1950-MHz TD-SCDMA electromagnetic fields for up to 48 h did not act as a cytotoxic or tumor-promoting agent to affect the proliferation or gene expression profile of glioblastoma cells. Conclusions: Our findings implied that exposing brain tumor cells in vitro for up to 48 h to 1950-MHz continuous TD-SCDMA electromagnetic fields did not elicit a general cell stress response.
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    • "The application of electromagnetic fields (EMFs) is ubiquitous in modern society [1]. Several epidemiological and experimental studies have shown that EMF exposure may have detrimental effects on cognitive function [2,3] and may increase the risk of neurological diseases, such as gliomas [4,5] and Alzheimer’s disease [6,7]. EMF exposure has also been demonstrated to induce strong glial reactivity in different brain regions [8-10]. "
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