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Ann M. O’Hare, Ronit Katz, Michael G. Shlipak, Mary Cushman and Anne B.
Results From the Cardiovascular Health Study
Mortality and Cardiovascular Risk Across the Ankle-Arm Index Spectrum:
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total and cardiovascular mortality. This confirms similar
reports in Native Americans enrolled in the Strong Heart
Study and in a large cohort of Japanese hemodialysis patients.
Although AAI values ?0.9 were associated with higher
mortality among CHS participants, this was also true of AAI
values between 0.9 and 1.0 and AAI values ?1.4. Further-
more, the specific association of AAI with mortality and
cardiovascular risk varied between men and women and
between older and younger subjects and depended on whether
we used the lowest or highest leg AAI.
Dr O’Hare is supported by a Research Career Development Award
from the Department of Veterans Affairs Health Services Research
and Development Service. Dr Shlipak is funded by R01
HL073208-01 and by the American Federation for Aging Research
and National Institute on Aging (Paul Beeson Scholars Program) and
the Robert Wood Johnson Foundation (Generalist Faculty Scholars
Program). The CHS Study is supported by contracts N01-HC-85079
through N01-HC-85086, N01-HC-35129, and N01 HC-15103 from
the National Heart, Lung, and Blood Institute. A full list of
participating CHS investigators and institutions can be found at
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O’Hare et alAAI, Mortality, and Cardiovascular Risk
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