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Effects of Psychotherapy for Depression in Children and Adolescents: A Meta-Analysis

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Serious sequelae of youth depression, plus recent concerns over medication safety, prompt growing interest in the effects of youth psychotherapy. In previous meta-analyses, effect sizes (ESs) have averaged .99, well above conventional standards for a large effect and well above mean ES for other conditions. The authors applied rigorous analytic methods to the largest study sample to date and found a mean ES of .34, not superior but significantly inferior to mean ES for other conditions. Cognitive treatments (e.g., cognitive-behavioral therapy) fared no better than noncognitive approaches. Effects showed both generality (anxiety was reduced) and specificity (externalizing problems were not), plus short- but not long-term holding power. Youth depression treatments appear to produce effects that are significant but modest in their strength, breadth, and durability.
... We expect that EMDR therapy is associated with a significant reduction in depressive and comorbid symptoms. We consider this of great importance, given the limited effectiveness of current psychotherapies for adolescent MDD [8,56]. ...
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Background Major depressive disorder (MDD) is one of the most common mental disorders in adolescence carrying a serious risk of adverse development later in life. Extant treatments are limited in effectiveness and have high drop-out and relapse rates. A body of literature has been published on the association between distressing/ traumatic experiences and development and maintenance of MDD, but the effectiveness of a trauma-focused treatment approach for MDD has hardly been studied. This study aims to determine the effectiveness of eye movement desensitization and reprocessing (EMDR) therapy as stand-alone intervention in adolescents diagnosed with MDD. Methods This study will be a randomized controlled trial with two conditions: (1) EMDR treatment (6 sessions) and (2) waiting list condition (WL: 6 weeks, followed by EMDR treatment). First, participants receive a baseline measure after which they will be randomized. Participants will be assessed post-intervention after which the WL participants will also receive six EMDR sessions. Follow-up assessments will be conducted at 3 and 6 months follow-up. Study population: In total, 64 adolescents (aged 12–18) diagnosed with a major depressive disorder (DSM-5) and identified memories of at least one distressing or traumatic event related to the depressive symptomatology will be included. Main study parameters/endpoints: Primary outcome variables will be the percentage of patients meeting criteria for MDD classification, and level of depressive symptoms. Secondary outcome measures include symptoms of PTSD, anxiety, and general social-emotional problems. At baseline, family functioning and having experienced emotional abuse or neglect will be assessed to explore whether these factors predict post-treatment outcome. Discussion With the present study, we aim to investigate whether EMDR as a trauma-focussed brief intervention may be effective for adolescents with a primary diagnosis of MDD. EMDR has been proven an effective treatment for traumatic memories in other disorders. It is hypothesized that traumatic memories play a role in the onset and maintenance of depressive disorders. Particularly in adolescence, early treatment of these traumatic memories is warranted to prevent a more chronic or recurrent course of the disorder. Trial registration International Clinical Trial Registry Platform (ICTRP): NL9008 (30–10-2020).
... At individual level, there are effective psychological interventions for mental health difficulties in children and young people, supported where appropriate by pharmacological treatments. In general, cognitive behaviour therapy (CBT) is the first choice of treatment for anxiety (Compton et al., 2004;National Institute for Health andCare Excellence, 2013, 2014), depression (Compton et al., 2004;National Institute for Health and Clinical Excellence, 2005;Weisz et al., 2006;Munoz-Solomando et al., 2008), and post-traumatic stress disorder (National Institute for Clinical Excellence, 2005;Silverman et al., 2008;Kowalik et al., 2011). There is also an evidence base to support family therapy for eating disorders in children and young people (Lock et al., 2010; National Institute for Health and Care Excellence, 2017). ...
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In this study, the Adolescent Behavioral Activation Program (A-BAP) based on behavioral activation (BA) therapy to reduce depressive symptoms in adolescents was adapted to Turkish culture, and its effectiveness was tested with intervention design, one of the mixed method designs. In this direction, experimental and control groups were formed with 20 students studying in three different high schools in Turkey and with highly elevated depressive symptoms. The study group was determined by nested sampling from mixed-method sampling strategies. The starting point of this study is the absence of any BA-based practice to reduce adolescent depression in Turkey. In this direction, experimental and control groups were formed with 20 students studying in three different high schools in Turkey and with highly elevated depressive symptoms. The adapted A-BAP was applied individually to the students in the experimental group for 12 weeks. Three sessions were also held with the parents of the students in the experimental group. In the quantitative phase of the study, pre-test and post-test control groups paired patterns from semi-experimental designs, and a case study was used in the qualitative stage. The qualitative data of the study were collected from adolescents and their parents through semi-structured interviews and session evaluation forms. It was determined that the adapted BA-based A-BAP was an effective intervention in reducing depressive symptoms in the Turkish adolescent sample and provided a significant decrease in the depression scores of the participants in the experimental group . The qualitative findings show that adolescents perceive the A-BAP process as a factor contributing to making them feel better. Adolescents have reported that A-BAP is effective in reducing avoidance behavior, achieving anger control, and increasing self-esteem and social interaction. Parents consider A-BAP as a developer, educator, and practice that reduces depressive symptoms in their children. In addition, it was determined that the qualitative findings obtained supported the quantitative results. Since the study is the first application of BA therapy in Turkey, it is thought that it will contribute to new studies in Turkey and intercultural studies at the international level.
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The long-standing view that anxiety and depression are separate constructs has been challenged in the recent literature. Mainly on the basis of adult studies, it has been argued that anxiety and depression are part of a broader construct of emotional distress, currently referred to as negative affectivity. This article addresses the clinical-research evidence for negative affectivity in children and adolescents. Following an examination of the phenomenology of anxiety and depressive disorders, we review the empirical findings on the relations between these disorders. Of particular interest are diagnostic, assessment, and treatment studies. In general, the evidence suggests that there is an overlap between anxiety and depression in children and adolescents. Limited evidence suggests that developmental influences play an important role in the anxiety-depression relationship. The implications of a general state of emotional distress for child and adolescent behavior therapy are briefly discussed.
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The efficacy of short-term cognitive-behavioral therapy, relaxation training, and self-modeling interventions for the treatment of depression among middle school students was investigated. Sixty-eight moderate to severely “experimentally diagnosed” latency age and depressed early adolescent subjects (ages 10–14) were assigned randomly to one of three active treatments or waitlist-control. Self-report and interview measures of depression and self-esteem were used to assess treatment effects. Results indicated that all treatment conditions, relative to the waitlist-control, evidenced a significant decrease in depression and an increase in self-esteem. Parent-report data, as well as data from treated control subjects, provided further support for the potential effectiveness of the short-term structured school-based interventions.
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Over 40 years of development of cognitive behavioral approaches to treating anxiety and related emotional disorders have left us with highly efficacious treatments that are increasingly widely accepted. Nevertheless, these manualized protocols have become numerous and somewhat complex, restricting effective training and dissemination. Deepening understanding of the nature of emotional disorders reveals that commonalities in etiology and latent structure among these disorders supercedes differences. This suggests the possibility of distilling a set of psychological procedures that would comprise a unified intervention for emotional disorders. Based on theory and data emerging from the fields of learning, emotional development and regulation, and cognitive science, we identify three fundamental therapeutic components relevant to the treatment of emotional disorders generally. These three components include (a) altering antecedent cognitive reappraisals; (b) preventing emotional avoidance; and (c) facilitating action tendencies not associated with the emotion that is dysregulated. This treatment takes place in the context of provoking emotional expression (emotional exposure) through situational, internal, and somatic (interoceptive cues), as well as through standard mood-induction exercises, and differs from patient to patient only in the situational cues and exercises utilized. Theory and rationale supporting this new approach are described along with some preliminary experience with the protocol. This unified treatment may represent a more efficient and possibly a more effective strategy in treating emotional disorders, pending further evaluation.
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This chapter provides a discussion of school-based interventions aimed at treating youth with depression. The authors give an overview of depression in youth, including its clinical presentation in children and assessments that can be used to diagnose and monitor the disorder within the framework of a school setting. Also, the authors provide a review of school-based interventions with a focus on indicated programs. The ACTION (Stark et al., 1997) program is one such school-based intervention, and the authors give a discussion of the treatment components involved in this program. Finally, this chapter covers issues related to transportability of cognitive behavioral treatment (CBT) programs for youth into the schools, with a focus on school commitment, treatment parameters, environmental constraints, and training school staff.
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Background Psychotherapy is widely used for depressed adolescents, but evidence supporting its efficacy is sparse. Methods In a controlled, 12-week, clinical trial of Interpersonal Psychotherapy for Depressed Adolescents (IPT-A), 48 clinic-referred adolescents (aged 12-18 years) who met the criteria for DSM-III-R major depressive disorder were randomly assigned to either weekly IPT-A or clinical monitoring. Patients were seen biweekly by a "blind" independent evaluator to assess their symptoms, social functioning, and social problem-solving skills. Thirty-two of the 48 patients completed the protocol (21 IPT-A–assigned patients and 11 patients in the control group). Results Patients who received IPT-A reported a notably greater decrease in depressive symptoms and greater improvement in overall social functioning, functioning with friends, and specific problem-solving skills. In the intent-to-treat sample, 18 (75%) of 24 patients who received IPT-A compared with 11 patients (46%) in the control condition met recovery criterion (Hamilton Rating Scale for Depression score ≤6) at week 12. Conclusions These preliminary findings support the feasibility, acceptability, and efficacy of 12 weeks of IPT-A in acutely depressed adolescents in reducing depressive symptoms and improving social functioning and interpersonal problem-solving skills. Because it is a small sample consisting largely of Latino, low socioeconomic status adolescents, further studies must be conducted with other adolescent populations to confirm the generalizability of the findings.
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Fifty-six fifth- and sixth-grade children, manifesting depressive symptoms as judged by teachers and in response to a self-report Depression Battery were assigned to one of the following 10-week intervention conditions: Role Play (treatment), Cognitive Restructuring (treatment), Attention Placebo, or Control. Both quantitative and qualitative improvements were observed for several children in the Role Play and Cognitive Restructuring treatments, though the gain was more dramatic in Role Play.