Population-based case-control study of allergic rhinitis during pregnancy for birth outcomes

Department of Respiratory Medicine, School of Medicine, Semmelweis University, Budapest, Hungary. <>
European Journal of Obstetrics & Gynecology and Reproductive Biology (Impact Factor: 1.7). 04/2007; 131(1):21-7. DOI: 10.1016/j.ejogrb.2005.11.035
Source: PubMed


Allergic rhinitis is frequent in women of childbearing age including pregnancy. The present study aimed to estimate the effect of maternal allergic rhinitis on birth outcomes, in particular congenital abnormalities, preterm birth and low birthweight newborns.
Analysis of the population-based data of the Hungarian Case-Control Surveillance of Congenital Abnormalities between 1980 and 1996.
The evaluation of data did not reveal any teratogenic potential of allergic rhinitis and indeed a lower prevalence of total congenital abnormalities was found. In addition, a protective effect could be observed for preterm birth due to longer gestational age (adjusted t=2.97, p=0.003).
Allergic rhinitis is not risk factor for pregnant women.

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Available from: Akos Somoskövi
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    • "Corticosteroids also induce dysregulation of placental hormone/cytokine gene expression and downregulation of the insulin-like growth factor-II/Akt signaling pathway, which may result in increased placental apoptosis, placental insufficiency, and fetal growth restriction (32). Although some studies showed that the prevalence of allergic rhinitis was lower in mothers of extremely LBW ( < 1,000 g) pre-term infants compared with mothers of full-term babies (33), others reported no association between maternal allergic rhinitis during pregnancy and BW (27). The association between maternal allergic disease and BW of infant may be explained by the Developmental Origins of Health and Disease (DOHaD) theory (34). "
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    • "In accordance with the finding that allergic disease is associated with shorter waiting time to pregnancy73,74, higher birth weight and less preterm births89,90, it has also been suggested that the Th2-like immunity associated with allergic disease could promote a development of Th2 immune responses in the offspring 91. "
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    • "Allergic disease is associated with shorter waiting time to pregnancy (Westergaard et al. 2003), longer gestational age, higher birth weight (Somoskovi et al. 2007) and less pre-term births (Savilahti et al. 2004). Thus, the Th2-like immunity associated with allergic disease might generate favourable effects on the likelihood of being pregnant and the maintenance of pregnancy. "
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