Influence of menstrual cycle phase on pulmonary function in asthmatic athletes

Biomedical Sciences, University of California-San Diego, La Jolla, CA 92093, USA.
Arbeitsphysiologie (Impact Factor: 2.19). 04/2006; 96(6):703-10. DOI: 10.1007/s00421-005-0067-7
Source: PubMed


The main aim of this study was to investigate whether there is a relationship between menstrual cycle phase and exercise-induced bronchoconstriction (EIB) in female athletes with mild atopic asthma. Seven eumenorrheic subjects with regular 28-day menstrual cycles were exercised to volitional exhaustion on day 5 [mid-follicular (FOL)] and day 21 [mid-luteal (LUT)] of their menstrual cycle. Pulmonary function tests were conducted pre- and post-exercise. The maximal percentage decline in post-exercise forced expiratory volume in 1 s (FEV(1)) and forced expiratory flow from 25 to 75% of forced vital capacity (FEF(25-75%)) was significantly greater (P<0.05) on day 21 (mid-LUT phase) (-17.35+/-2.32 and -26.28+/-6.04%, respectively), when salivary progesterone concentration was highest, compared to day 5 (mid-FOL phase) (-12.81+/-3.35 and -17.23+/-8.20%, respectively), when salivary progesterone concentration was lowest. The deterioration in the severity of EIB during the mid-LUT phase was accompanied by worsening asthma symptoms and increased bronchodilator use. There was a negative correlation between the percent change in pre- to post-exercise FEV(1) and salivary progesterone concentration. However, no such correlation was found between salivary estradiol and the percentage change in pre- to post-exercise FEV(1). This study has shown for the first time that menstrual cycle phase is an important determinant of the severity of EIB in female athletes with mild atopic asthma. Female asthmatic athletes may need to adjust their training and competition schedules to their menstrual cycle and to consider the potential negative effects of the LUT phase of the menstrual cycle on exercise performance.

Download full-text


Available from: Martin R Lindley, Apr 22, 2015
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Much attention has been given in this report to the potential fallacies of skin tests in the diagnosis of allergies of the immediate type. Yet after 100 years, skin tests are still a valuable diagnostic tool for the allergist. It is essential, however, to avoid the pitfall of placing too much emphasis on either the positive or negative skin test. No test, whether in vivo or in vitro, old or newly developed, provides the final diagnosis. To hand the patient a list of inhalants and foods to which he or she is 'allergic' based solely on positive skin tests is indefensible. The physician needs a thorough knowledge of his patient. Any diagnostic test, including skin testing, must be interpreted in the clinical light, in terms of the history and physical examination.
    Preview · Article · Feb 1974 · Medical Clinics of North America
  • Source

    Full-text · Article · Jan 2007 · Revista Brasileira de Medicina do Esporte
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: OBJETIVO: Describir los mecanismos del asma inducido por el ejercicio (AIE), así como los efectos de diferentes tipos de entrenamiento físico sobre la función pulmonar y las capacidades aeróbica y anaeróbica. Se destaca la importancia de un diagnóstico correcto mediante el test de ejercicio y el manejo o uso de drogas beta-adrenérgicas y anticolinérgicas. FUENTES: Los artículos fueron cuidadosamente escogidos utilizando las bases de dados de PubMed y Scielo por el año de publicación, dando preferencia a ensayos clínicos randomizados, con criterios de selección de muestra bien definidos. SÍNTESES DE DATOS: Los mecanismos para explicar la AIE permanecen sin conclusión, pero parece haber una interacción fisiológica entre las hipótesis aquí presentadas. El uso de medicamentos y las frecuentes crisis durante el ejercicio aparecen como factores limitantes para la práctica de ejercicios físicos, conduciendo esto a un estilo de vida sedentario. CONCLUSIÓN: Se debe incentivar la práctica de ejercicios debidamente prescritos y minimizar las restricciones a los individuos con AIE.
    Full-text · Article · Feb 2007 · Revista Brasileira de Medicina do Esporte
Show more