Congenital syphilis in the United Kingdom

Sexually Transmitted Infections (Impact Factor: 3.4). 03/2006; 82(1):1. DOI: 10.1136/sti.2005.019349
Source: PubMed
Download full-text


Available from: Ian Simms
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: to evaluate the prevalence of maternal syphilis at delivery and neonatal syphilis infection in an Italian urban area, in connection with the increased flow of immigration. A prospective surveillance study was carried out in Bologna, Italy, from November 2000 to March 2006. All pregnant women were screened for syphilis at delivery. Infants born to seropositive mothers were enrolled in a prospective follow-up. During the study period 19,205 women gave birth to 19,548 infants. A total of 85 women were seropositive for syphilis at delivery. The overall syphilis seroprevalence in pregnant women was 0.44%, but it was 4.3% in women from eastern Europe and 5.8% in women from Central-South America. Ten women were first found positive at delivery, as they did not receive any prenatal care. Nine of these were from eastern Europe. All their infants were asymptomatic, but six had both reactive immunoglobulin (Ig)M western blot and rapid plasma reagin tests and were considered prenatally infected. Three of six were preterm (gestational age <37 weeks). In Italy, congenital syphilis infection is strictly related to immigration from eastern Europe. Although it is asymptomatic, it could cause premature delivery. Therefore, it is necessary to perform serological tests during the third trimester in mothers coming from endemic areas to adequately treat syphilis in pregnancy and prevent congenital infection. If the mother's test results are not available at delivery, it is necessary to investigate the newborn, especially if it is born prematurely.
    Full-text · Article · Apr 2007 · Sexually Transmitted Infections
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Congenital syphilis was rare in most affluent countries but there has been a slight resurgence recently in several European countries. In large parts of the world and particularly sub-Saharan Africa congenital syphilis is a significant public health problem. The cornerstone of congenital syphilis control is antenatal screening and treatment of mothers with penicillin, which is a cost-effective intervention. In affluent countries it should be strengthened among those at high risk. Clinicians should be more vigilant for the possibility of babies being born with congenital syphilis, which is often asymptomatic. In developing countries not only does antenatal care screening need to be strengthened by implementing point-of-care decentralised screening and treatment but alternative innovative approaches to controlling congenital syphilis should be explored. There is an urgent need for international health agencies to support focused approaches to tackling the tragedy of continuing congenital syphilis. This could be a part of a pro-poor strategy to meet the Millennium Development Goals.
    Full-text · Article · Jul 2007 · Seminars in Fetal and Neonatal Medicine
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Congenital syphilis still poses a significant public health problem in many countries of the world. We studied epidemiology of syphilis and other sexually transmitted infections among pregnant women and their newborns during a 5-year period at a general hospital in Valera, western Venezuela finding a high incidence of disease among those newborns from infected mothers.
    Full-text · Article · Sep 2007 · Journal of Tropical Pediatrics
Show more