Endoplasmic Reticulum Stress-Induced Apoptosis and Autoimmunity in Diabetes

ArticleinCurrent Molecular Medicine 6(1):71-7 · March 2006with14 Reads
Impact Factor: 3.62 · DOI: 10.2174/156652406775574613 · Source: PubMed

    Abstract

    Increasing evidence suggests that stress signaling pathways emanating from the endoplasmic reticulum (ER) are important to the pathogenesis of both type 1 and type 2 diabetes. Recent observations indicate that ER stress signaling participates in maintaining the ER homeostasis of pancreatic beta-cells. Either a high level of ER stress or defective ER stress signaling in beta-cells may cause an imbalance in ER homeostasis and lead to beta-cell apoptosis and autoimmune response. In addition, it has been suggested that ER stress attributes to insulin resistance in patients with type 2 diabetes. It is necessary to study the relationship between ER stress and diabetes in order to develop new therapeutic approaches to diabetes based on drugs that block the ER stress-mediated cell-death pathway and insulin resistance.