Article

Gunter MJ, Stolzenberg-Solomon R, Cross AJ, et al. A prospective study of serum C-reactive protein and colorectal cancer risk in men

Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, Maryland 20852, USA.
Cancer Research (Impact Factor: 9.33). 03/2006; 66(4):2483-7. DOI: 10.1158/0008-5472.CAN-05-3631
Source: PubMed

ABSTRACT

Chronic inflammation has been implicated in the etiology of colorectal cancer. C-reactive protein (CRP), a sensitive marker of inflammation, has been investigated with regard to colorectal cancer in only three previous studies, and the results from these investigations were inconsistent. We examined serum CRP levels in relation to colorectal cancer incidence in a nested case-control study within the Alpha Tocopherol, Beta-Carotene (ATBC) Cancer Prevention Study, a cohort of 29,133 Finnish males enrolled from 1985 to 1988 with follow-up through April 2002. Colorectal cancer cases were ascertained by the Finnish Cancer Registry; this analysis included 130 cases of colorectal cancer (with available blood), which occurred between 1990 and April 30, 2002, and 260 matched controls. Baseline median CRP levels were approximately 25% higher among colorectal cancer cases (3.4 mg/L) than controls (2.6 mg/L; P = 0.04). Relative to men in the lowest quartile of CRP concentration, men in the highest quartile had an odds ratio of 2.9 (95% confidence interval, 1.4-6.0) for developing colorectal cancer with a dose-response relationship supported (P(trend) = 0.006). The relation between CRP and incident colorectal cancer was modified by body mass index such that the association was stronger among lean individuals than in heavier individuals (P(interaction) = 0.018). These results support the notion that chronic low-grade inflammation is a marker for increased risk of colorectal cancer.

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Available from: Richard J Wood, Apr 23, 2014
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    • "Chronic inflammation is considered a risk factor for many common malignancies including cancers of the breast[1], lung[2], and colon[3]. Colorectal cancer is the third most common type of cancer and the third leading cause of cancer-associated mortality in both males and females in the United States[4]. "
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    • "Cyclooxygenase-2 inhibitors and nonsteroidal anti-inflammatory drugs (NSAIDs) were found to decrease the incidence of colorectal adenoma, and NSAIDs were also found to reduce the incidence of CRC [4]. Elevated C-reactive protein (CRP), which is a marker of systemic inflammation was reported as the risk factor for CRC [5]. "
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    • "These results suggest the predictable potency of CRP in the mortality of CRC patients. Therefore, the results of the present study to a certain extent confirmed the conclusions of a number of previous studies which considered the positive pathological role of CRP in CRC (32–34,43). Possible reasons for the difference between the previous studies which indicated a negative association between CRP levels and clinical and pathological features in CRC patients, and other previous positive studies including the present one are probably partly attributable to the variable potential biological features, different stages, distribution of the patient population and the disparate territory. "
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