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Nathan, C. Neutrophils and immunity: challenges and opportunities. Nat Rev Immunol 6: 173-182

Department of Microbiology and Immunology, Weill Cornell Medical College, Weill Graduate School of Medical Sciences of Cornell University, Box 57, 1300 York Avenue, New York 10021, USA.
Nature reviews. Immunology (Impact Factor: 34.99). 04/2006; 6(3):173-82. DOI: 10.1038/nri1785
Source: PubMed

ABSTRACT

Scientists who study neutrophils often have backgrounds in cell biology, biochemistry, haematology, rheumatology or infectious disease. Paradoxically, immunologists seem to have a harder time incorporating these host-defence cells into the framework of their discipline. The recent literature discussed here indicates that it is appropriate for immunologists to take as much interest in neutrophils as in their lymphohaematopoietic cousins with smooth nuclei. Neutrophils inform and shape immune responses, contribute to the repair of tissue as well as its breakdown, use killing mechanisms that enrich our concepts of specificity, and offer exciting opportunities for the treatment of neoplastic, autoinflammatory and autoimmune disorders.

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    • "Activation of neutrophils with microbial or inflammatory stimuli results in the release of neutrophil extracellular traps (NETs)[4]. NETs are extracellular web-like structures consisting of cfDNA with histones, granules, and cytoplasmic proteins, including neutrophil elastase (NE), myeloperoxidase, cathepsin G, proteinase 3, gelatinase, LL-37, lactoferrin, and calprotectin[26,27]. These structures bind to microorganisms , prevent them from spreading, and ensure a high local concentration of neutrophil granule enzymes to kill bacteria and fungi[4]. "
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