13.06.13 07:09Antimicrobial peptides are present in immune... [Cell Tissue Res. 2006] - PubMed - NCBI Download full-text
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Cell Tissue Res. 2006 Jun;324(3):449-56. Epub 2006 Feb 24.
Antimicrobial peptides are present in immune and host defense cells of the
human respiratory and gastrointestinal tracts.
Wah J, Wellek A, Frankenberger M, Unterberger P, Welsch U, Bals R.
Department of Anatomy, Chair II, Ludwig Maximilian University, 80336 München, Germany.
Previous studies have implicated antimicrobial peptides in the host defense of the mammalian
intestinal and respiratory tract. The aim of the present study has been to characterize further the
expression of these molecules in non-epithelial cells of the human pulmonary and digestive
systems by detailed immunohistochemical analysis of the small and large bowel and of the large
airways and lung parenchyma. Additionally, cells obtained from bronchoalveolar lavage were
analyzed by fluorescent activated cell sorting and immunostaining of cytospin preparations. hBD-
1, hBD-2, and LL-37 were detected in lymphocytes and macrophages in the large airways, lung
parenchyma, duodenum, and colon. Lymphocytes positive for the peptides revealed a staining
pattern and distribution that largely matched that of CD3-positive and CD8-positive T-cells.
Macrophages with positive staining for the antimicrobial peptides also stained positively for CD68
and CD74. In view of the morphology of the LL-37-positive and hBD-2-positive mucosal
lymphocytes, they are probably also B-cells. Thus, antimicrobial peptides of the defensin and
cathelicidin families are present in a variety of non-epithelial cells of mucosal organs. These
findings confirm that antimicrobial peptides have multiple functions in the biology of the mucosa of
PMID: 16501999 [PubMed - indexed for MEDLINE]
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