[Observation on therapeutic effect of acupuncture on recurrent oral ulcer].

College of TCM, Capital Medical University, Beijing 100013, China.
Zhongguo zhen jiu = Chinese acupuncture & moxibustion 02/2006; 26(2):103-4.
Source: PubMed


To compare therapeutic effects of acupuncture and routine western medicine is an recurrent oral ulcer of the type of accumulation of heat in the heart and spleen.
Seventy-four cases were randomly divided into 2 groups. The acupuncture group of 37 cases were treated with acupuncture at Tongli (HT 5), Gongsun (SP 4), Neiting (ST 44), Hegu (11 4), etc. The control group of 37 cases were treated with VitB2 , VitC. Their therapeutic effects were compared.
The total effective rate was 83.8% in the treatment group and 48.6% in the control group with a very significant difference between the two groups (P<0.01).
The therapeutic effect of acupuncture is significantly better than that of the control group, and acupuncture is an effective therapy for recurrent oral ulcer of type of accumulation of heat in the heart and spleen.

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    ABSTRACT: In East Asian countries, acupuncture is used to treat wounds; however, the therapeutic mechanism is not well established. In this study, the effects of acupuncture on wound healing and the therapeutic mechanism was investigated in C57BL/6 mice. A 4-mm biopsy punch was used to create four full-thickness wounds on the dorsum of the mice on BL48 and BL51. The wound healing effects were compared in three groups after wounding; an untreated group was used as the negative control, and acupuncture-treated (on BL49 and BL52) and Madecassol® ointment-treated groups were used as the positive controls. The wounds were digitally photographed and the wound size was measured daily until 10 days after wounding. The wound closure was quantified using CANVAS 7SE software. The wound tissues were collected at 24 h and 48 h after wounding for the PCR analysis of VEGF, TGF-β1, and bFGF expression. The wounds in the acupuncture-treated group closed more rapidly than in the other groups, and at 6 days after wounding, a statistically significant difference was observed. The expression of VEGF mRNA (F (3, 23) = 18.47, P < 0.0001) and TGF-β1 mRNA (F (3, 21) = 8.547, P = 0.0007) in the acupuncture-treated group was increased at 48 h after wounding. The expression of bFGF mRNA (F (3, 24) = 5.398, P = 0.0055) was increased in the acupuncture-treated group; however, compared with the untreated group, the difference was not statistically significant. Therefore, acupuncture accelerated the wound healing via the activation of angiogenic growth factors.
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