Discovery of Indole-Containing Tetracycles as a New Scaffold for Androgen Receptor Ligands.

ArticleinBioorganic & Medicinal Chemistry Letters 16(12):3233-7 · July 2006with4 Reads
Impact Factor: 2.42 · DOI: 10.1016/j.bmcl.2006.03.047 · Source: PubMed


    A novel series of tetracyclic indoles have been designed, synthesized and evaluated as androgen receptor (AR) ligands. Studies of structure-activity relationships (SARs) were investigated, which led to some compounds in this series as strong binders to androgen receptors.