Structure—Activity Studies of Oxazolidinone Analogues as RNA-Binding Agents.

ArticleinBioorganic & Medicinal Chemistry Letters 16(13):3600-4 · August 2006with7 Reads
Impact Factor: 2.42 · DOI: 10.1016/j.bmcl.2006.03.068 · Source: PubMed

    Abstract

    We have synthesized and tested a series of novel 3,4,5-tri- and 4,5-disubstituted oxazolidinones for their ability to bind two structurally related T box antiterminator model RNAs. We have found that optimal binding selectivity is found in a small group of 4,5-disubstituted oxazolidinones.