Determining the Size and Shape Dependence of Gold Nanoparticle Uptake into Mammalian Cells

Institute of Biomaterials & Biomedical Engineering, University of Toronto, Toronto, Ontario M5S 3G9, Canada.
Nano Letters (Impact Factor: 13.59). 05/2006; 6(4):662-8. DOI: 10.1021/nl052396o
Source: PubMed


We investigated the intracellular uptake of different sized and shaped colloidal gold nanoparticles. We showed that kinetics and saturation concentrations are highly dependent upon the physical dimensions of the nanoparticles (e.g., uptake half-life of 14, 50, and 74 nm nanoparticles is 2.10, 1.90, and 2.24 h, respectively). The findings from this study will have implications in the chemical design of nanostructures for biomedical applications (e.g., tuning intracellular delivery rates and amounts by nanoscale dimensions and engineering complex, multifunctional nanostructures for imaging and therapeutics).

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Available from: Devika B Chithrani, Dec 06, 2015
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    • "[68,69] GNPs were also found to predominantly accumulate in the endosomes and small fractions were observed in the cytosol and mitochondria. [70,71] The rate of the GNPs cellular uptake relies on the size, shape, charge of the coating surface molecules.72737475 Manipulating GNPs coating surface molecules can enhance the cellular uptake of the GNPs. "

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