Metalloproteases see the light

Nature Chemical Biology (Impact Factor: 13). 06/2006; 2(5):229-30. DOI: 10.1038/nchembio0506-229
Source: PubMed

ABSTRACT

Small-molecule probes that chemically tag targets by virtue of their enzymatic activities offer a means to focus system-wide experiments and provide functional information for entire families of proteins. Recent advances in the design and application of light-activated probes that target metalloproteases have created the opportunity to study this medically important family of enzymes in unprecedented detail.

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Available from: Matthew Bogyo
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