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Efficacy of aloe vera cream in prevention and treatment of sunburn and suntan

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Abstract

The efficacy of aloe vera cream in prevention of burn and tan from ultraviolet were studied in 20 volunteers. The minimal erythema dose of 20 volunteers were tested. The mean MED was 40-60 mj. The well preserved containing 70% of aloe vera cream. The aloe vera cream was applied randomized double blind technique on the test sites 30 minutes before, immediately after, or both before and after then the serial ultraviolet UVB 40,50,60,70,80 mj were radiated. MED reading at 24 hour for sunburn evaluation. Erythema and pigmentation were evaluated by visual grading 1-4 score. The aloe vera cream was continuing applied at the test sites twice daily for the the next three weeks. The results showed that the aloe vera cream has no sunburn or suntan protection and no efficacy in sunburn treatment when compared to placebo. The aloe vera cream has no bleaching effect too.

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... 14,22 When human skin is exposed to UVB, it is absorbed by keratinocyte DnA. 16,23 On the other hand, its wavelength is responsible for vitamin D synthesis. 21,24 UVC covers wavelengths between 200 and 280 nm, and this spectrum is also called "germicidal" due to its biocidal effects on bacteria. ...
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Problems caused by increasing multidrug resistance and contamination sources around the world, as well as major infectious events such as the COVID-19 pandemic, affect the world on a global scale. For this reason, there is a need to investigate sterilization and disinfection methods and to develop new environmentally friendly methods with a wide range of implementation capacity. In this study, the effect of ultraviolet-C (UVC) irradiation on different microorganisms was investigated with different application times. In addition,observations were made about the presence of reactivation in microorganisms with dark and light applications. Staphylococcus aureus, Bacillus cereus, Escherichia coli, Klebsiella pneumoniae were selected as test organisms for in vitro experimental studies. When all results were evaluated, it was found that E.coli was most affected by UVC among microorganisms. A direct ratio was determined between application duration and the lethal effect. These results provide information about time required for UVC application, which is an environmentally friendly method for killing these microorganismsresponsible for major infections. In addition, the reactivation properties of microorganisms were also examined with varying results. It was determined that the number of reactivated microorganisms were high in the light application compared to the dark application, but for some microorganisms, the reactivation was high at dark application.
... Since ancient times, it has been hailed as a universal panacea for its use in cosmeticology such as treating sunburn 10 Lastly, studies on multirooted teeth or teeth with abnormal root morphology can be conducted. ...
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Introduction: Intracanal medicaments & effective irrigation are the contributing factors for the overall healing process of endodontic infection. Calcium hydroxide is proven to be highly effective in endodontic treatment. In dentistry, natural herbs have been widely used in various treatment procedures. Among them, Moringa oleifera & Aloe vera have proven their medicinal properties. However, there is not much information about the effect of these herbs on their ease of removal from the root dentin. Objective: To evaluate and compare the ease of removal of these herbal based intracanal medicaments using a stereomicroscope. Method: Thirty single-rooted premolar teeth were decoronated at the cemento-enamel junction. Canals were prepared using hand files till size 45, then randomly divided into 3 groups (n = 10); Group 1: Ca(OH)2 saline paste, Group 2: Ca(OH)2 Moringa oleifera paste, and Group 3: Ca(OH)2 Aloe vera paste. The access cavity was sealed with Cavit™ and kept in the incubator at 37 °C. The intracanal medicament paste was removed after 1 week using a standardized irrigation solution. Root canals were sectioned bucco-lingually and subjected for the evaluation using a stereomicroscope at 25× magnification. Results were analysed using Kruskal-Wallis H Test and Mann Whitney Test with a p value <0.05. Results: A Kruskal-Wallis H test showed that there was no statistically significant difference in Ca(OH)2 remnants between the three different materials, χ2(2) = 0.035, p = 0.983. The Ca(OH)2 Aloe vera paste showed the highest residual remnants with statistically no significant difference with other two groups. Conclusion: Moringa oleifera performed equally to saline and has a favourable outcome as compared to Aloe vera in terms of ease of removal from the root canal system, hence it is recommended as vehicle for future studies.
... Miazga pochodząca z liści zawiera aminokwasy, antrazwiązki, minerały, enzymy, ligninę, mono-i polisacharydy, saponiny, sterole i witaminy [18]. Wykorzystywany jest w leczeniu ran i oparzeń skóry oraz w prewencji i leczeniu poparzeń słonecznych [49,50,51]. Ekstrakt z liści aloesu użyty jako kontrola w badaniach oceny fotoprotekcyjnych właściwości roślin o zastosowaniu leczniczym na Sri Lance wykazał SPF 28,86±0,11 [52]. ...
Article
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W obliczu wzrastającej zachorowalności na nowotwory skóry zalecane jest stosowanie kremów przeciwsłonecznych o szerokim spectrum ochrony. W celu zapewnienia ochrony w zakresie od 290 nm do 400 nm w kosmetykach stosowane są filtry fizyczne i chemiczne. Surowce i substancje pochodzenia naturalnego wykazujące właściwości absorbujące promieniowanie UV używane są w celu ograniczenia ilości filtrów chemicznych stosowanych w kosmetykach. Substancje te wykazują dodatkowo działanie antyoksydacyjne, przeciwzapalne oraz immunomodulujące dostarczając ochrony przed szkodliwymi skutkami ekspozycji na promieniowanie UV. W pracy zostały opisane surowce i substancje pochodzenia naturalnego wykazujące potencjalne działanie fotoprotekcyjne. Większość przebadanych naturalnych substancji i wyciągów roślinnych posiada jednak zbyt niski wskaźnik ochrony przeciwsłonecznej (SPF), by mogły być stosowane samodzielnie w kremach do opalania, natomiast mogą one stanowić cenny składnik kremów o niskim SPF do codziennego użytku.
... The Aloe Vera cream has no bleaching effect too. However, this may be bene icial in treating the symptoms [50]. ...
Book
The sunscreen industry is achieving remarkable worldwide prominence by responding to the growing need for skin protection with fast-paced innovation. Increased consumer awareness of the harmful effects of sunlight has fueled the demand for improved photo protection. The need for broad-spectrum protection from both UVA and UVB rays has inspired scientists worldwide to research new cosmetic formulations and delivery systems. More effective sunscreen actives, emollients and novel cosmetic and functional ingredients have been regularly added to the formulator’s repertoire. Creativity in innovation has been hindered only by regulatory agencies and patent restrictions worldwide. Familiarity with the current restrictive regulations and patent law infringements has become integral to any research effort attempting to provide improved protection to individuals affected by the sun’s damaging effects. The increasing incidence of skin cancers and photo damaging effects caused by ultraviolet radiation has increased the use of sun screening agents, which have shown bene􀏐icial effects in reducing the symptoms and reoccurrence of these problems. Unlike the situation in Europe where sunscreen ingredients are considered under cosmetics guidelines, the FDA is required to de􀏐ine sunscreens as drugs since they are advertised to prevent sunburn and, more recently, the risk of skin cancer. In the USA, the FDA has been regulating this industry since August 25, 1978, with the publication of the Advance Notice of Proposed Rulemaking. Sunscreens are considered drugs and cosmetics and therefore must be governed by the FDA-OTC monograph. With the variety of sunscreen agents used in cosmetic and UV protection products, Australia, Canada, and the European Union (EU) have also developed regulatory protocols on safe sunscreen product use. Unlike the USA though, Australia has approved 34 active sunscreen ingredients and the EU has approved 28 of these ingredients. Current FDA regulations allow labeling of sunscreen products to a maximum of 30þ, despite the many products currently available with numbers as high as 100. From a cosmetic formulation point of view, increasing the SPF number in a product is governed by simple chemical principles
... The Aloe Vera cream has no bleaching effect too. However, this may be beneficial in treating the symptoms [18].  Topical anesthetics: Advertised remedies such as topical anesthetics (benzocaine) may help with symptoms of sunburn, however, very little clinical data is available to substantiate their effectiveness. ...
Preprint
Full-text available
The sunscreen industry is achieving remarkable worldwide prominence by responding to the growing need for skin protection with fast-paced innovation. Increased consumer awareness of the harmful effects of sunlight has fueled the demand for improved photo protection. The need for broad-spectrum protection from both UVA and UVB rays has inspired scientists worldwide to research new cosmetic formulations and delivery systems. More effective sunscreen actives, emollients and novel cosmetic and functional ingredients have been regularly added to the formulator’s repertoire. Creativity in innovation has been hindered only by regulatory agencies and patent restrictions worldwide. Familiarity with the current restrictive regulations and patent law infringements has become integral to any research effort attempting to provide improved protection to individuals affected by the sun’s damaging effects. The increasing incidence of skin cancers and photo damaging effects caused by ultraviolet radiation has increased the use of sun screening agents, which have shown beneficial effects in reducing the symptoms and reoccurrence of these problems. Unlike the situation in Europe where sunscreen ingredients are considered under cosmetics guidelines, the FDA is required to define sunscreens as drugs since they are advertised to prevent sunburn and, more recently, the risk of skin cancer. In the USA, the FDA has been regulating this industry since August 25, 1978, with the publication of the Advance Notice of Proposed Rulemaking. Sunscreens are considered drugs and cosmetics and therefore must be governed by the FDA-OTC monograph. With the variety of sunscreen agents used in cosmetic and UV protection products, Australia, Canada, and the European Union (EU) have also developed regulatory protocols on safe sunscreen product use. Unlike the USA though, Australia has approved 34 active sunscreen ingredients and the EU has approved 28 of these ingredients. Current FDA regulations allow labeling of sunscreen products to a maximum of 30þ, despite the many products currently available with numbers as high as 100. From a cosmetic formulation point of view, increasing the SPF number in a product is governed by simple chemical principles.
... In the pathogenesis of erythema, UV light stimulates the release of histamine, kinins, and prostaglandins that cause damage to keratinocytes. The minimal erythema dose (MED) is defined as the minimum amount of radiation that can cause skin erythema and can be observed up to 24 h after exposure to sunlight [8]. Skin exposed to sunlight will produce erythema quickly or slowly and can cause browning of the skin (tanning) [9,10]. ...
Article
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Objective: The aim of this study is to evaluate the physical stability of two lotion formulations containing Selaginella plana and Lagenaria siceraria(Molina) Standl. and investigated their safety and efficacy to relieve erythema due to exposure to the sun.Methods: We conducted a randomized controlled trial consisting of five treatment groups: Negative control, positive control, neutral control, formulaA test group (containing a 1% ethanolic fraction of S. plana and a 0.5% ethanolic fraction of L. siceraria [Molina] Standl.), and formula B test group(containing a 0.5% ethanolic fraction of S. plana and a 1% ethanolic fraction of L. siceraria [Molina] Standl.). Each group had erythema induced byexposure to sunlight for 30 min between 10:00 and 16:00. The severities of erythema 1, 3, and 24 h after application were assessed.Results: Formula A was significantly better than formula B (p<0.05) at reducing the severity of erythema.Conclusion: Formula A containing a 1% ethanol fraction of S. plana and a 0.5% ethanol fraction of L. siceraria (Molina) Standl. showed the greatestreduction in the level of erythema (p<0.05). S. plana may reduce the prostaglandin synthesis caused by sun exposure.
... En los tratamientos naturales sencillos se incluye el uso de paños húmedos y fríos en las zonas quemadas por el sol, la aplicación de lociones calmantes que contienen aloe vera. El gel extraído directamente de una planta de aloe vera funciona mejor (11,12). Otros tratamientos incluyen el uso de una crema hidratante que contiene soja, aguacate, manteca de karité. ...
Article
Full-text available
We carry out a practical review of the prevention and treatment of sunburn or actinic, caused by sunlight or artificial lamps.
... En los tratamientos naturales sencillos se incluye el uso de paños húmedos y fríos en las zonas quemadas por el sol, la aplicación de lociones calmantes que contienen aloe vera. El gel extraído directamente de una planta de aloe vera funciona mejor (11,12). Otros tratamientos incluyen el uso de una crema hidratante que contiene soja, aguacate, manteca de karité. ...
Article
We carry out a practical review of the prevention and treatment of sunburn or actinic, caused by sunlight or artificial lamps.
... The herb used in the multi-purpose formulation is Aloe vera, using the ethanol for the extraction process. Aloe vera, was selected on the basis of a documented literature [2][3][4][5][6][7][8] . ...
Article
Despite the increase in the number of cosmetic preparations containing antioxidant, sun protection, moisturizing agents, chiefly, due to their actions in preventing the process of skin aging, there is a need to develop herbal formulation in order to obtain safe, stable and multipurpose high efficient quality products. The present study was to develop and evaluate and compare the hydrating, erythema & sun protection of the herbal o/w cream comprising extract of natural product from Aloe vera, in the appropriate concentration. Different types of formulations oil in water (O/W) were formulated by incorporating different concentrations of different concentrations 0f the extract, 2.5, 5, 10 and 20 % namely and the base, F1 to F8. The evaluations of all formulations (F1 to F8) were done on different parameters like pH, viscosity, spreadability and stability were examined. Formulations F1 and F4 showed good spreadability, good consistency, homogeneity, appearance, pH, spreadability, no evidence of phase separation and ease of removal. The formulations F1-F4were selected for the animal studies. All formulations F1-F4 in concentrations of 2.5, 5, 10 and 20 % herbal extract. They showed no redness, edema, inflammation and irritation during irritancy studies. These formulations are safe to use for application to check the other parameters. Formulation F3 in concentration 5% showed the best hydration and photo-protection properties. These studies suggest that composition of the extract and the base of the cream of F3 is more appropriate, stable and safe, it may produce synergistic action. Key words: Aloe vera, o/w cream, Hydration, erythema, Photo-protection.
... Aloe vera is commonly known as aloe or Gwar patta (Hindi), belonging to the family Liliaceae. This plant is used in digestive problems, asthma, peptic ulcer, skin irritation, burns, wound, eczema, acne, psoriasis, dermatitis and diabetes (Puvabanditsin and Vongtongsri, 2005;Reuter et al., 2008;Mohamed, 2011;Yagi et al., 2011). Fresh juice of this plant leaf contains 96% water and mucilage. ...
Article
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p class="Abstract">Wound occurs due to disruption of soft tissues that results from injury. Recently many medicinal plants have been demonstrated for wound healing potential through in vivo and in vitro preclinical models and their mechanisms of wound healing has also been reported. Medicinal plants have been reported to show wound healing potential via angiogenesis, activation of NF-κB, favoring pro-inflammatory cytokines, increased expression of inducible nitric oxide synthase (iNOS) and alpha 1 type 1 collagen, and anti-oxidant activity. Thus, in this review, an attempt was made to give an insight into the recently reported medicinal plants with wound healing mechanisms which could be beneficial in therapeutic practice and development of new wound healing drugs for human use.</p
... Throughout history, this herb has been used in humans to cure disorders associated with the digestive system such as poor digestion, constipation, anorexia, abdominal distension, colitis, and conditions such as diabetes, asthma, and uterine pain (Sahu et al., 2013). It has been also used to treat abrasions, burns and skin irritations, acne, and dermatitis (Puvabanditsin & Vongtongsri, 2005;Sahu et al., 2013). Several studies have reported antibacterial anti-inflammatory immune-modulatory effects (Gautam et al., 2004;Madan et al., 2008;Moorthy et al., 2009), and antioxidation properties (El-Shemy et al., 2010) of Aloe vera. ...
Article
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This study investigated the effects of dietary Aloe vera powder extract on the activities of digestive enzymes and muscle composition of Oreochromis niloticus (GIFT strain) juveniles. Five dietary groups were formulated in which A. vera powder was added into a tilapia feed at 0.5%, 1.0%, 2.0%, and 4%/kg feed, and fed for eight weeks. Amylase, trypsin, and lipase activities in the liver and along the alimentary canal (stomach, midgut, and hindgut) varied significantly between dietary groups. Amylase activity was significantly enhanced in the liver of fish fed 0.5, 1, and 2% dietary A. vera, and in the stomach of those fed 1%. Total amylase activity in the gastrointestinal tract (total gut) was significantly enhanced in fish fed 0.5% and 1% compared with control and those fed 4% dietary A. vera. Trypsin activity was significantly enhanced in the stomach of fish supplemented with 0.5% dietary A. vera and in the duodenum of those supplemented with 1%, 2%, and 4% dietary A. vera when compared with the control. Lipase activity was increased in the duodenum of fish fed 1.0% dietary A. vera when compared with the control. Muscle moisture content was significantly lower in all A. vera-supplemented fish, whereas protein was lower in those fed 2% and 4% A. vera diet when compared with the control. Based on second-order polynomial regression analysis, dietary A. vera inclusion level less than or equal to 1.76%, 1.82%, 2.10%/kg feed was determined to be suitable in enhancing carbohydrate, protein and lipid digestion, respectively, in GIFT tilapia in this study. ______________________________________________________________________________________
... Aloe vera is used to obtain antibacterial, antiviral, antimycotic, wound healing and anti-inflammatory effects (Eshun and He, 2004). Ginseng: Ginseng is promoted as an adoptogen, and root of the ginseng plant is the most valued form (Puvabanditsin and Vongtondsri, 2005). Ginseng extract can be used by way of the microencapsulation technique to protect the skin from cancer and inflammation. ...
... Once human skin is exposed to UVB, it is absorbed by DNA of keratinocyte. [27] Its high energy radiation, which is dependent on its wavelength, causes not only sunburn but also skin ageing, skin cancer, etc. [28] To avoid the harmful effects of repeated exposure to ultraviolet radiation, personal protection, Personal measures are needed. The interaction of UVR with skin surface causes biochemical changes in collagen, elastin and connective tissues, there by resulting into break down of collagen and elastin fibers of the skin by enzymes collagenase and elastate that are responsible for maintaining the skin firmness and elasticity, and skin deterioration start to occur. ...
... 6 The herb is used in various conditions like digestive problems, asthma, immune system enhancement, peptic ulcer, externally in skin irritation, burns, scalds, sunburn wounds, eczema, acne, psoriasis, dermatitis, ulcers. 7,8 Aloe Vera also having antidiabetic activity. 9,10 There are established evidences on elevated levels of serum creatinine and urea being reduced by aloe vera in combination with standard antidiabetic drugs. ...
Article
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p> Having an anti-diabetic activity, Aloe Vera (Aloebarbadensis) has been used for medicinal purposes in several cultures for millennia. It has also been proved that aloe vera is having protective activity in nephrotoxic rats.The objective of the pres­ent study was to evaluate the effect of Aloe vera leaves extract on diabetic nephropathy in Streptozotocin-induced diabetic rat. Diabetes was induced by Streptozotocin(60 mg/kg-i.p.). Four weeks later rats were randomly selected and divided into 5 groups (n=6). Group I: normal control. Group II: diabetic nephropathy (DN) control. Group III: DN+AVE (250 mg/ kg). Group IV: DN+AVE (500 mg/kg). Group V: DN+AMG (1 mg/1ml in drinking water). The treatment was given for 8 weeks. Various parameters like physiological, antidiabetic, renal function, antioxidants and histopathology were measured. Administration of aloe vera extract showed significant decrease in body weight, food and water intake, kidney weight, blood glucose level, serum creatinine, BUN, protein in urine, serum uric acid and lipid peroxidation. It also significantly increases the plasma insulin level, liver glycogen content, urine volume, GFR, SOD, catalase, Reduced glutathione. Histopathologi­cal studies confirmed that administration of AVE prevented kidney damage, which provided structural support for the renal shielding effect. The significant effect of aloe vera extract on diabetic nephropathy could be due to the inherent antihy­perglycemic, antioxidant, improvement of renal function parameters. In the near future AVE could constitute a lead to the discovery of a novel drug for the treatment of diabetic nephropathy. </p
... Throughout history this herb has been internally used to cure disorders associated with the digestive systems like; poor digestion, constipation, poor appetite, abdominal distension, colitis, as well as conditions such as diabetes, asthma, and uterine pain (Arambewela and Alagiyawanna, 2006; Sahu et al., 2013). It has been also used externally to treat abrasions, burns and skin irritation, acne, and dermatitis (Arambewela and Alagiyawanna, 2006; Puvabanditsin and Vongtongsri, 2005; Sahu et al., 2013). Several studies have reported antibacterial, anti-inflammatory, immune-modulatory effects Effect of dietary aloe (Aloe vera) on sex ratio, growth and physiological responses in GIFTtilapia after streptococcus iniae challenge 40 (Gautam et al., 2004; Madan et al., 2008; Moorty et al., 2009), and antioxidation properties (Shemy et al., 2010; Nwaoguikpe et al., 2010) of Aloe vera. ...
Thesis
Two separate experiments were carried out in this study. Experiment 1 studied the effect of dietary Aloe vera on sex ratio of GIFT-tilapia (Oreochromis niloticus) fry. Five groups were designed including a control (basal diet) and 100% Aloe powder included in fish feed at 0.5, 1, 2, and 4% /kg feed, which was administered for 30 days. Fish fed 2.0% and 4.0% dietary aloe significantly deviated from the expected 1:1, male: female sex ratio, in favor of males (X2 = 10.08, P<0.05; X2 = 26.08, P<0.05), respectively, with 4% presenting the highest percentage of males (67.62%). Contrariwise, survival percentage in fish fed 4% aloe diet was observed to be significantly lower (P<0.05) among groups. Furthermore, experiment 2 used the same research design as in experiment 1 to investigate the effect of dietary Aloe on growth performance, physiological responses, and disease resistance against Streptococcus iniae in GIFT-tilapia juveniles, after 60 days administration. Fish fed 0.5%, 1%, and 2% A. vera supplemented diet significantly improved (P<0.05) weight gain, absolute growth rate, and specific growth rate. Based on the second order polynomial analysis relation on WG or SGR, the optimum dietary aloe inclusion level suitable for growth was estimated to be 1.96% /kg feed. Moreover, feed intake significantly increased in fish fed with Aloe diet at 1% and 2% /kg feed. Feed efficiency ratio, feed conversion ratio, and hepatosomatic index was significantly enhanced in 4% aloe supplemented fish over unsupplemented ones (P<0.05). Furthermore, dietary aloe significantly influenced concentration of the digestive enzymes and muscle composition of GIFT-tilapia juveniles, and based on the second-order polynomial regression analysis, dietary aloe inclusion level less than or equal to 1.76, 1.82, 2.10% /kg feed were determined suitable for amylase, trypsin, and lipase secretion in GIFT-tilapia, respectively. Several haemato-biochemical indices were examined before and after fish were challenged with S. iniae pathogen containing 7.7x106 CFU cells mL-1. Aloe supplemented fish showed a significant increase (P<0.05) in red blood cells (RBC), haematocrits (Ht), hemoglobin (Hb), white blood cells (WBC), neutrophils, monocytes, eosinophils, serum total protein, glucose, cortisol, complement (C3 and C4), after challenge when compared to unsupplemented ones. Meanwhile, 4% Aloe supplemented fish showed a decrease (P<0.05) in RBC, Hb, Ht, WBC, and mean corpuscular hemoglobin (MCH) after challenge compared to unsupplemented ones and other supplemented ones. In addition, lower mean corpuscular volume values (MCV) (P<0.05) were observed in fish fed with aloe diet at 2% and 4% aloe /kg feed than those fed unsupplemented diet. Unchallenged fish fed 0.5%, 1%, and 2% aloe showed significantly higher values (P<0.05) of mean corpuscular hemoglobin concentration (MCHC) than those fed unsupplemented diet and 4% aloe supplemented diet. There was a significant increase (P<0.05) in the neutrophil to lymphocyte ratio (NLCR) within experimental groups after challenge; NLCR in aloe unsupplemented fish and those supplemented with aloe diet at 1% /kg feed increased significantly (P<0.05) throughout challenge period; while those fed 4% aloe supplemented diet maintained higher values at all experimental stages among groups. There was a significant correlation (P<0.05, r = 0.53) between NLCR and glucose concentration, 96 hours after challenge. Aloe had no significant effect (P>0.05) on the survival of the fish when compared to the control; no mortality was recorded during challenge trial. Furthermore, fish fed dietary aloe at 4% /kg feed significantly reduced (P<0.05) in total cholesterol (TC), while triacylglycerol (TG) reduced in those fed 0.5%, 2%, and 4% aloe /kg feed compared to unsupplemented ones. High-density lipoprotein (HDL) was significantly elevated in fish fed 0.5% and 1% aloe /kg feed compared to unsupplemented ones and no significant changes (P>0.05) were noted in low-density lipoprotein (LDL) among test groups. Furthermore, high activities of superoxide dismutase (SOD), Catalase (CAT), and glutathione peroxide (GSH-Px) in liver tissues were observed in aloe supplemented fish compared to unsupplemented ones, before and after S. iniae challenge. Variations were also noted in malondialdehyde (MDA) activity throughout the trial, but no significant difference (P>0.05) was observed between groups. Meanwhile, aloe supplemented fish reduced in serum aspartate and alanine aminotransferase (AST and ALT) activities before and after challenge. Overall, our results indicated that 100% aloe powder could be potential sex reversal agent, growth promoter, appetizer, meat quality enhancer, anti-depressant, immunostimulants, antioxidant, and hepatoprotective promoter especially during disease outbreaks in tilapia culture. However, before aloe could be recommended as an all male tilapia producing technique or tilapia feed additives to improve their growth performance and other physiological parameters, more studies including extract purification and development of a perfect treatment regime to produce 100% male tilapia population are deemed necessary.
... There are various reports on the uses of this plant for treatment of arthritis, gout, rheumatism, acne, burns, pain and gastrointestinal tract ulcers (7,8). Aloe Vera gel causes healing of wounds and burns, lesions due to exposure to UV rays are also improved by this gel (9)(10)(11). Anti-cancer, anti-bacterial, and anti-inflammatory activities have also been observed in Aloe Vera plant, which are attributed to glycoprotein and polysaccharides (12)(13)(14). ...
Article
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Introduction: Aloe Vera or yellow Sabr is a durable plant belonging to Sousanian family. This plant has a strange potential to treat scars and burns. Aloe Vera leaf has antimicrobial and anticancer attributes. This study is designed to assess the probable effects of Aloe Vera sap on progesterone, estrogen and gonadotropin in female rats. Materials and Methods: In this experimental study, 40 female rats with the mean weight of 180 ± 20 gr were divided into five groups of control, sham, and intervention groups 1, 2, and 3. The control group did not receive any drug. The sham group only received 2 ml distilled water. Intervention groups received 50, 100 and 200 mg/ kg hidroalcoholic extract of Aloe Vera during 10 days orally (equal to 2 sexual cycles). Finally, the rats were anesthetized using ether and blood samples were taken through their ventricles. Blood serum was extracted and the serum concentration of estrogen, progesterone, luteinizing hormone (LH) and follicle-stimulating hormone (FSH) was measured using immunoassay. Data were analyzed using one-way ANOVA. Results: The mean serum level of estrogen was significantly higher in intervention groups 2 (100 mg) and 3 (200 mg) compared to the control group (P
... Topical application of aloe vera has also been shown to have tumor chemopreventative properties by decreasing both the number and size of papillomas induced by 7,12-dimethylbenz(a)anthracene in mice [7]. In another study, however, aloe vera cream was not found to be protective against the development of a sunburn [8], nor did it prevent UV-induced edema [9]. Therefore this suggests that the role of aloe vera in sunscreen remains unclear. ...
Article
The use of botanical products and vitamins in skin care creams and sunscreens is prevalent. Herein we conduct an evaluation of sunscreens to quantitatively assess how often sunscreens incorporate botanically derived products and vitamins. The most commonly used botanicals products and vitamins are identified and stratified based on the sunscreen sun protection factor (SPF). The overall prevalence for the use of botanical agents and vitamins was 62% and 79%, respectively. Aloe vera and licorice root extracts were the most common botanical agents used in sunscreens. Retinyl palmitate was the most common vitamin derivative utilized in sunscreens. The prices of sunscreens significantly increased when more than one botanical product was added. Botanical products and vitamins are widely utilized in sunscreens and more research is needed to assess how their inclusion may enhance or alter the function of sunscreens.
... A small randomized placebocontrolled trial gave hopeful preliminary evidence over 44 individuals teated with oral Aloe vera gel (100 mL twice daily for 4 weeks) was advantageous in the supervision of ulcerative colitis [104]. Puvabanditsin et al., [105] carried out a double-blind, randomized, placebo-controlled study to review the usefulness of Aloe vera cream in prevention of burn and tan from ultraviolet light. ...
Article
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Aloe vera (L.) Burm. f. (Family Liliaceae) is an evergreen perennial succulent plant widely used from antiquity. Aloe vera contains various carbohydrate polymers, notably glucomannans, along with a range of other organic and inorganic components. Phenolic compounds have been identified so far as chromone, anthraquinone or anthrone derivatives. Three distinct preparations of aloe plants are mostly used in medicinal practices that are quite different in their chemical composition and their therapeutic properties, aloe latex (aloe); aloe gel (Aloe vera); and, aloe whole leaf (aloe extract). Aloe latex is used for its laxative effect; aloe gel is used topically for skin ailments, such as wound healing, psoriasis, genital herpes and internally by oral administration in diabetic and hyperlipidaemic patients and to heal gastric ulcers; and, aloe extract is potentially useful for cancer and AIDS. Aloe vera possesses several pharmacological properties such as promoting and healing wound and burn, frost-bite healing, with addition to having antiinflammatory, antifungal, hypoglycemic and gastroprotective properties. This review explored the phytochemical and pharmacological knowledge as well as several promising aspects for research on aloe.
... It is internally used to cure disorders associated with the digestive systems like poor digestion, constipation, poor appetite, abdominal distention, colitis, as well as conditions such as diabetes, asthma, and uterine pain (Arambewela and Alagiyawannas 2006;Sahu et al. 2013). Aloe has also been used externally to treat abrasions, burns and skin irritation, acne, and dermatitis (Arambewela and Alagiyawannas 2006; Puvabanditsin and Vongtongsri 2005;Sahu et al. 2013). Several studies have reported antibacterial, anti-inflammatory, immunomodulatory effects (Gautam et al. 2004;Madan et al. 2008;Moorthy et al. 2009), and antioxidation properties (El-Shemy et al. 2010;Nwaoguikpe et al. 2010) of A. vera. ...
Article
The current study investigated the effects of dietary Aloe vera on plasma lipid profile status, antioxidant and hepatoprotective enzyme activities of GIFT-tilapia juveniles under Streptococcus iniae challenge. Five dietary groups were designed including a control and 100% Aloe powder incorporated into a tilapia feed at 0.5%, 1%, 2%, and 4% /kg feed, which were administered for 8 weeks. Fish fed dietary Aloe at 4% /kg feed significantly reduced in total cholesterol (TC), while triacylglycerol (TG) reduced (P < 0.05) in those fed 0.5%, 2%, and 4% Aloe /kg feed compared to unsupplemented ones. High-density lipoprotein (HDL) was significantly elevated in fish fed 0.5% and 1% Aloe /kg feed compared to unsupplemented ones and no significant changes (P > 0.05) were noted in low-density lipoprotein (LDL) among test groups. Furthermore, high activities of superoxide dismutase (SOD), Catalase (CAT), and glutathione peroxide (GSH-Px) in liver tissues were observed in Aloe supplemented fish compared to unsupplemented ones, before and after S. iniae challenge (7.7x106 CFU cells mL-1). Variations were also noted in malondialdehyde (MDA) activity throughout the trial, but no significant difference (P > 0.05) was observed between groups. Meanwhile, Aloe supplemented fish reduced in serum aspartate and alanine aminotransferase (AST and ALT) activities before and after challenge. Based on the second order polynomial regression analysis, dietary Aloe inclusion levels less than or equal to 1.88%, 1.86%, and 2.79% /kg feed was determined to be suitable in improving plasma lipid profile status, antioxidant and hepatoprotective enzyme activities in GIFT-tilapia in this study, respectively. Thus, A. vera extracts may be recommended as a tilapia feed supplement to enhance fish antioxidant and hepatoprotective capacities especially during disease outbreaks.
... No caso de queimaduras solares a mesma eficácia não pôde ser comprovada. De acordo com trabalho randomizado e duplo cego publicado por Puvabanditsin & Vongtongsri (2005) o creme contendo 70% de A. vera não exerceu efeito protetor ou auxiliou no tratamento de queimadura solar em 20 voluntários testados. ...
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A Aloe vera (L.) Burm.f. tem sido utilizada há milhares de anos na medicina tradicional para o tratamento de diversos males. O intuito desse trabalho foi o levantamento bibliográfico de artigos que evidenciassem a atividade farmacológica da Aloe vera. A revisão contemplou livros e periódicos nacionais e internacionais indexados nas bases de dados MEDLINE, LILACS e SciElo, nos idiomas português, inglês e espanhol, utilizando as palavras-chave citadas. Após o levantamento bibliográfico, constatou-se que várias atividades biológicas são atribuídas a Aloe vera. Evidências sugerem eficácia no tratamento da psoríase, herpes genital, queimaduras e hiperglicemia. Além disto, também foram demonstradas atividades antineoplásica, antimicrobiana, anti-inflamatória e imunomodulatória por estudos in vitro e in vivo, entretanto, na cicatrização de feridas, os resultados foram conflitantes. No tratamento de dermatite por radiação e em queimaduras solares sua eficácia não foi comprovada e foram relatados casos de hepatite aguda devido ao consumo de preparações orais. Tendo em vista as várias atividades comprovadas e poucos relatos acerca de sua contra indicação, conclui-se que o uso desta espécie corrobora o vasto uso popular.
... Similarly, Aloe vera, the other widely used medicinal plant for various cosmetic and drug preparations all over the world. This plant is also known to have sun screening effect and hence the use of this plant extract in skin creams offers sun protection benefits [7]. The potent skin lightening effect what we established for the combination of the extracts of Curcuma zedoaria and Aloe vera assumes great importance as both plants are widely used for various skin benefits. ...
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The objective of the study was to determine the effect of role of combination of extracts of Curcuma zedoaria and Aloe vera in reducing melanin synthesis. Varying concentrations of the extracts of the plants were tested for melanogenesis and tyrosinase activity in murine melanoma cells. Extract combinations at a concentration of 1-5µl showed 50- 150% reduction in melanogenesis without altering the cell proliferation. Tyrosinase activity was very low in extract treated cells when compared to control.
... r Evidence: Puvabanditsin et al. conducted a double-blind, randomized, placebo-controlled study to assess the efficacy of A. vera cream in prevention of burn and tan from ultraviolet light. 103 Patients were excluded from this study if they were pregnant or taking photosensitizing medications. Twenty volunteers were included in this study, who were at least 18 years of age with no history of sun sensitivity or skin cancers in the family. ...
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ABSTRACT An evidence-based systematic review including written and statistical analysis of scientific literature, expert opinion, folkloric precedent, history, pharmacology, kinetics/dynamics, interactions, adverse effects, toxicology, and dosing.
... r Evidence: Puvabanditsin et al. conducted a double-blind, randomized, placebo-controlled study to assess the efficacy of A. vera cream in prevention of burn and tan from ultraviolet light. 103 Patients were excluded from this study if they were pregnant or taking photosensitizing medications. Twenty volunteers were included in this study, who were at least 18 years of age with no history of sun sensitivity or skin cancers in the family. ...
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An evidence-based systematic review including written and statistical analysis of scientific literature, expert opinion, folkloric precedent, history, pharmacology, kinetics/dynamics, interactions, adverse effects, toxicology, and dosing.
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Excessive exposure to ultraviolet radiation (UVR) causes harmful effects on human skin. Pre‐exposure application of sunscreen can be protective, but not after damage already has occurred. There is a need for agents that can be applied post‐UVR exposure to repair the damage. We investigated a novel compound, NEO400, that appears to meet this medicinal need. NEO400 was created by conjugating linoleic acid to perillyl alcohol. UVR was repeatedly administered to the skin of mice over several weeks, where it caused the typical signs of UV damage, including scaling of the skin, DNA damage, and elevated levels of inflammatory cytokines. However, when NEO400 was applied immediately post‐UVR, it triggered the appearance of markers for dermal stem cell proliferation, and no signs of skin damage emerged. Furthermore, when NEO400 was applied to skin that already had incurred significant damage, it accelerated skin healing. When applied individually, linoleic acid and perillyl alcohol were ineffective, indicating that they had to be conjugated in order to exert therapeutic efficacy. None of these skin‐protective effects could be achieved with Aloe vera gel, a popular and widely used post‐exposure remedy. Our study suggests that NEO400 holds potential as a regenerative treatment for excessively UVR‐exposed skin.
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Due to their great biocompatibility, biodegradability, andminimal immunogenicity, liposomes are now the most widelyemployed nanocarriers for a variety of hydrophobic and hydrophiliccompounds that may be biologically active. Additionally, liposomesdemonstrated improved drug solubility and regulated distribution.They also showed the ability to modify the surface of drugs fortargeted, extended, and sustained release. Liposomes can be thoughtof as having developed from traditional, long-circulating, targeted,and immunological liposomes to stimuli-responsive and activelytargeted liposomes based on their composition. More liposomes haveadvanced stages in clinical trials, and many liposomal-based drugdelivery systems are currently clinically licensed totreat severaldisorders, including cancer, fungal infections, and viral infections.This review discusses the composition, preparationprocedures, andclinical uses of liposomes.
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Skin is the largest non – parenchymal organ of the human body. It constitutes a natural barrier against pathogens and harmful environmental exposures and contributes to the human body's homeostasis. Conditions affecting the skin range from infections and injury to autoimmune diseases and cancer. Herbs have been used in the treatment of dermatological conditions for a long time. Traditional approaches to delivering herbs to the skin include ointments, gels, creams, and lotions. However, poor lipophilicity or hydrophilicity in most herbal preparations results in limited bioavailability and poor penetration, restricting their effectiveness. Nanotechnology-based approaches have a major potential to this end, showing promising results in enhancing transdermal penetration compared to traditional approaches. This review article summarizes such advances and sheds light on future directions on the use of nanotechnology-based strategies.
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Traditional textiles have been utilized for the purposes of covering, protection, support, and ornamentation. Recently, with the increasing tendency of people to care for their bodies in natural and healthy ways, it is not only textile products that have improved comfort properties such as temperature and humidity control, but also hygienic, odor-releasing, color and appearance changeable, advanced protective and functional clothing, home textiles or textile-based care products have stood out. Textile engineers, biochemists, pharmacists, cosmetics and health experts make important contributions to the field of cosmetics textiles with multidisciplinary studies. Various metallic, vegetable and animal originated ingredients are used in pure or derivative form to gain cosmetic functionality to textile products. Cosmetic textiles are designed to transfer an active agent serving for a cosmetic purpose during contact with human skin. The cosmetic and / or pharmaceutical components are transferred to the fabric forming the garment so that the component(s) can be transferred to the skin by the natural movement of the body over a long period of time. The aim of this study is to provide a general summary of the existing literature on the functionalities, characterizations and performance tests of cosmetic textiles to the national literature.
Chapter
The chapter discusses the use of several sustainable nanostructured materials extracted from carbohydrate, and protein based sources for their potential use in edible food packaging. The development of natural biopolymer based edible food packaging materials incorporated with nanostructured materials such as nanocellulose, nanochitosan, nanostarch, and others are gaining significant importance in preserving food products. The edible coating/films for food products such as fruits and vegetables, meat and meat products, cut fruits provide several advantages over other available post-harvest techniques including reduced plastic based waste, improved retention of color, texture, nutrients content of food products, etc. Further, the inclusion of bioactive components with the polymer based matrix as edible coating/film application provides added advantages such as antioxidant, antidiabetic, anticholesteremic, antihypertensive, etc. In line to this, a wide range of natural bioactive agents such as Aloe vera, curcumin, sandalwood oil, clove oil, honey, etc. are added to edible food packaging materials for their noteworthy health beneficial properties. In this regards, the nanostructured sustainable materials facilitated by bioactive agents can significantly improve the shelf life of perishable food products including fruits and vegetables, sea based products, meat and meat based products, milk products, etc.
Chapter
The terms cosmeceutical and evidence-based may not belong in the same phrase. Cosmeceuticals are considered by many scientists to represent fluff without stuff, and indeed the reader may come to a similar conclusion at the end of this chapter. Nevertheless, it is worthwhile to examine the state of the science for cosmeceuticals as they represent an ever-expanding field in dermatology with perhaps much yet unrealized promise. Cosmeceuticals extend beyond cosmetics to enhance skin functioning, usually aiming to return the skin to a more youthful state. For example, wrinkle-reducing moisturizers, antioxidant serums, and skin-lightening salves all fall into this category. Cosmeceuticals are somewhat confusing, however, as both prescription and over-the-counter (OTC) products have been labeled by this term. Drug cosmeceuticals include topical retinoids for improving dermal collagen production, topical minoxidil for enhanced scalp hair growth, and eflornithine for facial hair growth reduction. These products will not be discussed, as they are not available to the consumer except by prescription. The second category of cosmeceuticals includes OTC drugs, such as sunscreens and antiperspirants. These also are outside the realm of this chapter. The discussion will focus on cosmeceuticals that are topically applied for the purpose of improving skin appearance.
Article
Background: Aloe vera has been used to treat wounds since ancient times. However, the efficacy of Aloe vera for burns and split-thickness skin graft (STSG) donor sites are inconclusive. Methods: A double-blind, randomized, controlled trial was conducted. Patients who underwent STSG harvesting from the thigh were included. STSG donor sites were divided into two groups: Aloe vera group and placebo group. The visual analogue scale (VAS) score evaluated pain and complete epithelialization was assessed. We searched electronic databases and included only international clinical trials published in the English language. Results: Twelve patients with 24 donor sites participated. Times to complete epithelization for the Aloe vera and placebo groups were 11.5 + 1.45 and 13.67 + 1.61 days (p<0.05). VAS scores after wound dressing for the Aloe vera and placebo groups were 17.18 + 13.17 and 18.63 + 11.20. No statistical significance was found between groups. Five articles met the inclusion criteria: four involved burns and one involved STSG donor sites. Three studies of burn wounds demonstrated improved epithelization and one did not. The STSG donor site study indicated that wound healing time for the control group was significantly different from that of the Aloe vera and placebo groups. The healing rate was not statistically different between groups. Conclusion: Topical Aloe vera gel significantly demonstrated accelerated STSG donor site healing but did not show significant pain relief.
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Ultraviolet radiation (200-400 nm) is about %5 radiation from the sun. The UV content will depend on some factors including: season, tropic, time of days, altitude and specific atmospheric conditions. Long-term sunlight (UV-radiation) exposure is known to be associated with the development of sunstroke, sunburn and skin cancer. Many synthetic products commonly used to absorption, reflection and distribution of UV-rays, but chemical drugs cause some side effects such as irritant contact dermatitis, phototoxicity and photoallergy in human body. The herbal medicine has gained popularity for the treatment or prevention of a lot of public disease. This study is an overview of important various medicinal and aromatic plants for treatment and prevention of sunstroke and sunburn diseases based on harmful UV radiation. Scientific names and part used of these plants are detailed listed and 29 different plant taxa were determined. Most commonly used plants as follows: Juglans regia, Teucrium polium, Arctium minus and Cornus mas. Finally, the results presented can be used as a base for subsequent work related to traditional medicine and its contribution to allopathic medicine in Turkey.
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Glucomannans play a much broader role in human health then providing dietary fibre. They are biologically active molecules and can when added to the body imitate innate molecules found in different organs including surface carbohydrates on cells. This review considers the immunological role of exogenous glucomannans within animals and man. This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.
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Die Haut als Ich-bezogenes Organ des menschlichen Körpers dient auch der Kommunikation mit dem Gegenüber und wurde seit jeher bewusst in ihrer Erscheinung modifiziert. So reichen die Ursprünge kosmetischer Behandlungen durch Externa (auch zur Faltenbehandlung) viele Jahrtausende zurück. Schon im alten Ägypten spielten kosmetische Anwendungen, nicht nur bei Frauen, sondern auch bei Männern, eine große Rolle.
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'Evefresh' a proprietary siddha preparation (indian system of medicine) in the composed of Curcuma zedoaria and aloe vera. The combination of Curcuma zedoaria and aloe vera on tyrosinase inhibition in melanocyte and melanogenesis has been already established in our earlier studies (1, 2). The present paper proves the efficacy of 'Evefresh' in down regulating the melanogenesis in human volunteers by using the Mexameter as a melanin measuring aid and the findings are included in the paper.
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Cosmeceuticals represent functional cosmetics and skincare products. The cutaneous effect of a cosmeceutical is the combined action of the moisturizing abilities of the vehicle combined with the intent of the active ingredients. The most common antiaging effect of cosmeceuticals on the skin is to enhance barrier function and provide photoprotection. Areas of research in cosmeceutical ingredients include substances intended to improve skin function by activating a receptor, altering an enzyme, functioning as a cellular messenger, acting as an antioxidant, or providing anti-inflammatory capabilities. Cosmeceuticals are considered cosmetics and, because of their unregulated status, their manufacturers can only make appearance-related claims.
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The objective of the study was to determine the effect of role of combination of extracts of Curcuma zedoaria and Aloe vera in reducing melanin synthesis. Varying concentrations of the extracts of the plants were tested for melanogenesis and tyrosinase activity in murine melanoma cells. Extract combinations at a concentration of 1-5μl showed 50-150% reduction in melanogenesis without altering the cell proliferation. Tyrosinase activity was very low in extract treated cells when compared to control.
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The main aim of this article is to collect the scattered knowledge of Cosmetotextiles and present it to the world scientific community for scrutiny. Various aspects of Cosmetotextiles are compiled systematically and oriented towards product development. The technology of Cosmetotextiles is at the neonatal stage. The joint efforts of textile technologists, biochemists, cosmetic experts and medicos can achieve challenging targets in the field of Cosmetotextiles. Various derivatives of metals, plants and animals are used in pure and derivative form to generate cosmetic functionality in textiles. Various routes for the incorporation of cosmetic potentail in textiles are available, of which microencapsulation and the use of cyclodextrin as cage material are the most popular. The content of moisture on skin surface is a key parameter in maintaining skin elasticity and glowing potential. The characterization of Cosmetotextiles is a difficult task, but the Europeans have taken the lead by classifying and standardising the testing of the cosmetic effects of cosmetotextiles.
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Objective: To study the protective effects of the aqueous leaf extract of Aloe barbadensis(AEAB) on gentamicin and Cisplatin-induced nephrotoxic Wistar rats. Methods: In each model of nephrotoxicity, thirty adult male Wistar rats were evenly divided into 5 groups. Groups I and II served as untreated and model controls, respectively while groups III-V were the treatment groups which were pretreated with 100-200 mg/kg bodyweight per day of AEAB 1 h before each dose of the nephrotoxicants. On the 8th day(in case of gentamicin) and on 6th day(in case of Cisplatin), blood samples for serum urea, total protein and creatinine as well as some ions like sodium, potassium, chloride and uric acid while the rat kidneys for histology were obtained under inhaled diethyl ether anesthesia. Results: In the gentamicin nephrotoxic rats, 100-200 mg/kg bodyweight per day significantly attenuated elevations in the serum creatinine, total protein and blood urea nitrogen levels in dose related fashion and no treatment related effect on uric acid and ions, and attenuated the gentamicin-induced tubulonephrosis. Similar effects were also recorded in the Cisplatin model of acute renal injury. Conclusions: The nephroprotective effect of AEAB could be due to the inherent antioxidant and free-radical-scavenging principle(s) contained in the extract. In the near future, AEAB could constitute a lead to discovery of a novel drug for the treatment of drug-induced nephrotoxicity.
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Sun protection consists mostly of protection against UV light. UV protection is of importance in primary prevention of light-induced or light-aggravated skin changes, In addition, UV-protection is an efficient tool to slow-down extrinsic ageing and to prevent the associated skin cancer development. This review summarizes new developments of evidence-based methods of an efficient sun protection.
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Ultraviolet B (UVB) rays vary with time and season and are the major cause of sunburns. Sunburned skin is a leading risk factor for melanoma and non-melanoma skin cancers. Protection against exposure to UVB rays may be achieved by a combination of various approaches such as use of broad spectrum sunscreen formulations. UV radiations (UVR) absorbed by the skin surface can produce harmful compounds called free radicals or reactive oxygen species (ROS), which can cause skin cancer and premature aging. To reduce ROS generation and damage, researchers recommend using sunscreen to protect the skin from harmful UVR. The realm of possibilities in photoprotection may include the development of sunscreens which remain at the surface of the skin for a longer time and may incorporate antioxidants that can neutralize ROS. By quenching free radicals, antioxidants may aid photoprotection effect. This review focuses on photoprotection from UVB radiation and discusses potential herbal candidates with antioxidant properties that can serve as a strong barrier in cosmeceuticals to protect skin against harmful UVB rays.
Chapter
IntroductionMoisturizersPigment lightening agentsAntioxidantsCarotenoidsFlavonoidsPolyphenolsOther antioxidants used in post-resurfacing formulationsConclusion References
Article
The present study was carried out to investigate the effects of an Aloe vera leaf extract, along with its standard active ingredient aloin, on the isolated tail melanophores of Bufo melanostictus tadpoles, which are a type of disguised smooth muscle cells offering excellent in vitro opportunities for studying the effects of pharmacological and pharmaceutical agents. It was found that the leaf extract of A. vera and its active ingredient aloin induced powerful, dose-dependent, physiologically significant melanin aggregating effects in the isolated tail melanophores of B. melanostictus similar to those of adrenaline per se. These preliminary findings clearly demonstrate that the extract of A. vera and its active ingredient aloin cause melanin aggregation leading to skin lightening via alpha adrenergic receptor stimulation. The present study opens new vistas for the use of A. vera regarding its clinical application as a new nontoxic melanolytic agent for the treatment of hyperpigmentation.
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There is an increasing demand for the herbal drug treatment of various ailments and many plant drugs from Ayurvedic system are being explored globally. The biological activities from various clinical and preclinical studies have been included along with some patents arising from these plants. The original report acts as a quick reference for extracting the biological activities, specially the newly reported effects, of the following selected Indian medicinal plants Adhatoda vasica, Aegle marmelos, Aloe vera, Andrographis paniculata, Asparagus adscendents, Cinnamomum tamala, Coriandrum sativum, Cuminum cyminum, Curcuma longa, Emblica officinalis, Glycyrrhiza glabra, Hemidesmus indicus, Mucuna pruriens, Phyllanthus niruri, Solanum nigrum, Syzygium aromaticum, Terminalia chebula, Tinospora cordifolia, Withania somnifera, Zingiber officinale.
Article
Aloe vera Linne or aloe barbadensis Miller is a succulent from the Aloe family (400 different species), a tropical plant which is easily grown in hot and dry climates and widely distributed in Asia, Africa and other tropical areas. The use of aloe vera is being promoted for a large variety of conditions. The aim of this systematic review was to summarize all dermatology-oriented in vitro and in vivo experiments and clinical trials on aloe vera preparations. Extensive literature search were carried out to identify all in vitro and in vivo studies as well as clinical trials on the subject. Data were extracted from these in a predefined standardized manner. Forty studies were located. The results suggest that oral administration of aloe vera in mice is effective on wound healing, can decrease the number and size of papillomas and reduce the incidence of tumors and leishmania parasitemia by >90% in the liver, spleen, and bone marrow. Topical application of aloe vera is not an effective prevention for radiation-induced injuries and has no sunburn or suntan protection. It can be effective for genital herpes, psoriasis, human papilloma virus, seborrheic dermatitis, aphthous stomatitis, xerosis, lichen planus, frostbite, burn, wound healing and inflammation. It can also be used as a biological vehicle and an anti-microbial and antifungal agent and also as a candidate for photodynamic therapy of some kinds of cancer. Even though there are some promising results with the use of aloe vera for diverse dermatologic conditions, clinical effectiveness of oral and topical aloe vera is not sufficiently and meticulously explored as yet.
Article
The treatment of roentgen ray and radium ulcers with the fresh whole leaf of Aloe vera was first described by Collins and Collins1 in 1935. Wright2 in 1936 published an additional report on its use, stating that he had obtained gratifying results. The technic of application of both the fresh whole leaf and an ointment containing the intestinal contents of the leaf have been described by these men. Since the publication of these two papers many patients have undoubtedly been treated by this method. For the most part, however, the results are relatively unknown, since cases in which that treatment was used have been reported only by word of mouth or in the transactions of certain societies.3Any one who has seen the horrible suffering endured by patients with some of the late sequelae of roentgen and radium irradiation and who realizes the utter futility of previous
Article
Chronic UV irradiation profoundly damages the dermis of human and animal skin. These alterations were thought to be irreversible. Recently, we showed that substantial repair occurred in hairless mice after stopping UV exposure. A band of new connective tissue was laid down subepidermally. The present study focussed on whether repair would occur if animals were protected by sunscreens after dermal damage was induced and irradiation was continued. Albino hairless mice were exposed to Westinghouse FS20 sunlamps thrice weekly for 30 weeks. The daily dose of UV (UVB + UVA) was 0.17 J/cm2. Sunscreens of sun protection factors (SPF) 6 and 15 were applied after 10 and 20 weeks of irradiation. Biopsies were taken at 10, 20, 30, and 45 weeks of the experiment. With both sunscreens, especially SPF-15, previously damaged dermis was repaired during continued irradiation. Repair occurred in situ and, in severely damaged skin, in the novel form of subepidermal reconstruction zones of new connective tissue with parallel collagen bundles and a network of fine elastic fibers.
Article
A reflectance instrument was used to measure the variation in UVR-induced erythema at different positions on the back. The pre-irradiation erythema index decreased from top to bottom of the back but the increase in index remained constant for a fixed exposure dose. In contrast, the minimal erythema dose was higher at lower sites on the back. The measured erythemal response increased linearly with the logarithm of the radiation dose from approximately the minimal erythema dose up to at least fifteen times this value.
Sunscreen efficacy of Aloe vera com-paring with standard sunscreen (5% Paraami-nobenzoic acid) Thesis for Master of science. 173-176 ∑“ß·æ∑¬åå 425/11/05
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Vichitpun V. Sunscreen efficacy of Aloe vera com-paring with standard sunscreen (5% Paraami-nobenzoic acid). Thesis for Master of science. 173-176 ∑“ß·æ∑¬åå 425/11/05, 4:34 PM175 rS176J Med Assoc Thai Vol. 88 Suppl.4 2005 Faculty of Medicine Chulalongkorn University, 1989
Cultivation and clinical application of Aloe vera leaf
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Fine A, Samuel B. Cultivation and clinical application of Aloe vera leaf. Radiology 1983; 3: 735-6.
Effects of Aloe vera (Linn.) on vascular changes in burn model in rats. Master's thesis
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Thanamittramanee S. Effects of Aloe vera (Linn.) on vascular changes in burn model in rats. Master's thesis. Interdepartment of Physiology, Graduate School, Chulalongkorn University, 1997.
Treatment of HF acid burns
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Bracken WM, Cuppage F, Mcclaury RL, Kirwin C, Klaassen CD. Treatment of HF acid burns. J Occup Med 1985; 27: 735-9.
Effect of fresh Aloe vera gel in the treat-ment of third-degree Roentgen reaction on white rats
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Rowe TD. Effect of fresh Aloe vera gel in the treat-ment of third-degree Roentgen reaction on white rats. Chem Abst 1940; 34: 7437
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Klein AD, Penneys NS. Aloe vera. J Am Acad Derm 1988; 18: 714-20.
Sunscreen efficacy of Aloe vera comparing with standard sunscreen (5% Paraaminobenzoic acid) Thesis for Master of science
  • V Vichitpun
Vichitpun V. Sunscreen efficacy of Aloe vera comparing with standard sunscreen (5% Paraaminobenzoic acid). Thesis for Master of science.
Acute effects of ultraviolet radiation on the skin
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Norris PG, Gange RW, Hawk JLM. Acute effects of ultraviolet radiation on the skin. In: Fitzpatrick TB, Eisen AZ, Wolff K, Freedberg IM, editors. Dermatology in general medicine. 4 th ed. New York: Plenum Medical, 1993: 1651-8.