Short Synthesis of Skeletally and Stereochemically Diverse Small Molecules by Coupling Petasis Condensation Reactions to Cyclization Reactions

Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts, United States
Angewandte Chemie International Edition (Impact Factor: 11.26). 05/2006; 45(22):3635-8. DOI: 10.1002/anie.200600497
Source: PubMed


(Chemical Equation Presented) An efficient synthetic pathway to skeletally and stereochemically diverse molecules is described. Densely functionalized amino alcohols were readily synthesized through a Petasis three-component, boronic acid Mannich reaction. Their intramolecular cyclization provided a collection of diverse single-isomer compounds with 15 different types of skeletons in three to five steps.

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Available from: Giovanni Muncipinto, Nov 13, 2015
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