Han X, Jovicich J, Salat D, van der Kouwe A, Quinn B, Czanner S et al. Reliability of MRI-derived measurements of human cerebral cortical thickness: the effects of field strength, scanner upgrade and manufacturer. NeuroImage 32: 180-194

Boston University, Boston, Massachusetts, United States
NeuroImage (Impact Factor: 6.36). 09/2006; 32(1):180-94. DOI: 10.1016/j.neuroimage.2006.02.051
Source: PubMed


In vivo MRI-derived measurements of human cerebral cortex thickness are providing novel insights into normal and abnormal neuroanatomy, but little is known about their reliability. We investigated how the reliability of cortical thickness measurements is affected by MRI instrument-related factors, including scanner field strength, manufacturer, upgrade and pulse sequence. Several data processing factors were also studied. Two test-retest data sets were analyzed: 1) 15 healthy older subjects scanned four times at 2-week intervals on three scanners; 2) 5 subjects scanned before and after a major scanner upgrade. Within-scanner variability of global cortical thickness measurements was <0.03 mm, and the point-wise standard deviation of measurement error was approximately 0.12 mm. Variability was 0.15 mm and 0.17 mm in average, respectively, for cross-scanner (Siemens/GE) and cross-field strength (1.5 T/3 T) comparisons. Scanner upgrade did not increase variability nor introduce bias. Measurements across field strength, however, were slightly biased (thicker at 3 T). The number of (single vs. multiple averaged) acquisitions had a negligible effect on reliability, but the use of a different pulse sequence had a larger impact, as did different parameters employed in data processing. Sample size estimates indicate that regional cortical thickness difference of 0.2 mm between two different groups could be identified with as few as 7 subjects per group, and a difference of 0.1 mm could be detected with 26 subjects per group. These results demonstrate that MRI-derived cortical thickness measures are highly reliable when MRI instrument and data processing factors are controlled but that it is important to consider these factors in the design of multi-site or longitudinal studies, such as clinical drug trials.

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    • "Some of the well-recognised limitations of neuroimaging studies should also be mentioned. The accuracy of the thickness estimation may vary across the cortical surface due M A N U S C R I P T A C C E P T E D ACCEPTED MANUSCRIPT 19 to lower contrast-to-noise ratio in specific regions (Han et al., 2006), such as the cingulate, frontal and temporal polar cortices. Moreover, the grey/white ratio decreases with age and the changing grey/white contrast may increase the variability of thickness estimation across cortical mantle (Salat et al., 2009b). "
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    • "The final 20 scans were collected on a 3T Siemens MAGNE- TOM Trio Tim MRI scanner with the following high-resolution MPRAGE sequence: TR/TE = 2500/1900 ms, FA = 98, FOV = 250 mm 9 250 mm 9 250 mm, 1 mm isotropic voxels, sagittal partitions. It should be noted that Freesurfer morphometric procedures (described below) have been demonstrated to show good test–retest reliability across scanner manufacturers and across field strengths (Reuter et al. 2012; Han et al. 2006). In our sample, there were no significant volumetric differences between the two scanners for any of our OFC regions of interest (ROIs) or whole brain gray matter (all Ps C 0.19). "
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