Synthesis and Antiproliferative Activities of Indolin-2-one Derivatives Bearing Amino Acid Moieties.

University of Auvergne, Clermont, Auvergne, France
European Journal of Medicinal Chemistry (Impact Factor: 3.45). 07/2006; 41(6):709-16. DOI: 10.1016/j.ejmech.2006.03.021
Source: PubMed


A convenient synthesis of indolin-2-ones substituted in the 3 position by an aminomethylene group bearing different amino acid moieties is described. Their antiproliferative activities were evaluated toward a panel of human solid tumor cell lines (PC 3, DLD-1, MCF-7, M4 Beu, A549, PA 1) and healthy cell lines (a murine fibroblast L929 and a human fibroblast primary culture).

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