3-Substituted gem-cyclohexane sulfone based γ-secretase inhibitors for Alzheimer's disease: Conformational analysis and biological activity

ArticleinBioorganic & Medicinal Chemistry Letters 16(14):3839-42 · August 2006with2 Reads
Impact Factor: 2.42 · DOI: 10.1016/j.bmcl.2006.04.019 · Source: PubMed

Previously, chemistry effort on the gem-cyclohexane series of gamma-secretase inhibitors has focused on the 4-position of the cyclohexane ring. Recently chemistry has been directed towards the 3-position and substitution here has also provided compounds with high gamma-secretase activity.