Tamm-Horsfall protein knockout mice do not develop medullary cystic kidney disease

ArticleinKidney International 69(10):1914-5 · June 2006with21 Reads
DOI: 10.1038/sj.ki.5000411 · Source: PubMed
    • "The internalization of NaPi-IIa from the brush border membrane in response to the parathyroid hormone is also impaired in the absence of megalin [77]. Umod encodes the glycoprotein uromodulin, and its expres sion is widely used as a marker of the adult DT and LH segments [78]. Umod knockout mice do not display a phenotype [79], but Umod mutation in humans results in hyperuricemic nephropathy and medullary cystic kidney disease type 2 [80]. "
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