Preeclampsia in twin gestations: Association with IVF treatments, parity and maternal age

Faculty of Health Sciences, Ben-Gurion University of the Negev, Be'er Sheva`, Southern District, Israel
Journal of Maternal-Fetal and Neonatal Medicine (Impact Factor: 1.37). 04/2006; 19(3):141-6. DOI: 10.1080/14767050500246045
Source: PubMed


To identify maternal factors that increase the risk of preeclampsia in twin gestations and to investigate whether twins conceived by in vitro fertilization (IVF) lead to an increased risk of preeclampsia development.
A retrospective population-based cohort study of twin deliveries was performed. Maternal characteristics and perinatal outcomes were evaluated. Patients' data were obtained from a computerized database and analyzed using SPSS statistical package.
During the study period there were 2628 twin deliveries, and of these 3.1% had severe preeclampsia and 6.16% mild preeclampsia. Patients with severe preeclampsia were more likely to be primiparous, and to have significantly higher frequency of chronic hypertension, gestational diabetes mellitus (GDM), IVF treatments, cesarean delivery, preterm delivery and twin discordancy than in the normotensive patients. Chronic hypertension, pirimiparity, twin discordancy and maternal age were independent risk factors for the development of preeclampsia. In a multivariate regression model including IVF treatment, parity and maternal age as risk factors for preeclampsia, women younger than 35 years that conceived following IVF treatments had an independent risk factor for the development of preeclampsia.
IVF treatments in primiparous patients and age younger than 35 years are independent risk factors for preeclampsia. Twin discordancy is an additional independent risk factor for the occurrence of preeclampsia.

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    • "to develop preeclampsia. Notably, these patients had several additional risk factors for preeclampsia, including advanced maternal age (Coghill, Hansen & Littman, 2011; Joseph et al., 2005), a higher rate of infertility treatments (Erez et al., 2006) and chronic hypertension, which may contribute to the inherent risk of the combined endocrinopathy for the development of preeclampsia. These results may suggest that these two endocrinopathies, which modify an effect of one another, and are influenced by metabolic processes, might have an additive influence on the risk to develop hypertensive disorders during pregnancy. "
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    ABSTRACT: Objectives. Diabetes mellitus (DM) and hypothyroidism are each associated with increased rate of pregnancy complications. However, their combined morbidity during gestation is poorly studied. Therefore, the aims of this study were to determine the prevalence of the combined morbidity of DM & hypothyroidism and whether it is associated with adverse maternal and neonatal outcome. Study design. This population based retrospective cohort study included 87,213 women who had 232,293 deliveries. All deliveries were divided into the following groups: (1) hypothyroidism & DM (n = 171); (2) hypothyroidism (n = 1502); (3) DM (n = 13,324); and (4) deliveries of women with neither endocrinopathy, who served as a control group (n = 217, 296). Results. The prevalence of DM & hypothyroidism in our population was 0.17%. In comparisons to the other study groups, women with DM & hypothyroidism had higher rates of infertility (p < 0.001), preeclampsia (p < 0.001), chronic hypertension (p < 0.001), preterm birth (p < 0.001), and cesarean deliveries (p < 0.001). In Generalized Estimating Equations (GEE) model, hypothyroidism & DM was an independent risk factor for cesarean section (OR 3.46; 95% CI 2.53–4.75) and for preeclampsia (OR 1.82; 95%CI 1.16–2.84). Conclusion. The combination of DM & hypothyroidism is rare, yet it is associated with higher rate of infertility, cesarean sections, preterm deliveries, and hypertensive disorders of pregnancy than the rest of the population. This dual endocrinological combination is an independent risk factor for preeclampsia and cesarean section. These findings suggest that these patients are at risk for perinatal complications and should be followed and delivered as high risk pregnancies.
    Full-text · Article · Mar 2013 · PeerJ
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    • "This study has found that the odds of low birth weight were reduced with increasing maternal age and with a history of a previous pregnancy (either spontaneous or following IVF) (Nelson and Lawlor, 2011). Similarly to these findings, Erez et al reported that among patients with twin gestation who conceived through ART the rate of preeclampsia was higher in women younger than 35 years old than in older parturient (Erez, Vardi et al., 2006). These reports suggest that among patients who suffers from infertility the background maternal illness may be more severe and with clinical implication that is additive to the effect of maternal age. "

    Full-text · Chapter · Jan 2012
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    • "Perinatal mortality is also higher, mainly related to prematurity-related complications and fetal growth restriction (Sibai et al., 2000). Exactly why twin pregnancies have a higher incidence of PE is unclear but risk factors include chronic hypertension, primiparity, maternal age and conception by assisted reproduction technologies (ART; Erez et al., 2006). Concern has been raised regarding the rise in the twin birth rate related to the use of ART in the last three decades. "
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    ABSTRACT: The risk of pre-eclampsia (PE) increases in twin pregnancies, especially when assisted reproduction technologies (ART) are used. The aim of this study was to assess angiogenic/anti-angiogenic factors in maternal serum in the first trimester of twin pregnancies and establish if the mode of conception influences angiogenic status. This prospective study enrolled women with twin (n = 61) and singleton (n = 50) pregnancies. Dichorionic twin pregnancies were divided into two groups according to their mode of conception. Singleton pregnancies were used as the control group. Soluble fms-like tyrosine kinase (sFlt-1), free placental growth factor (PlGF) and soluble endoglin (sEng) concentrations were measured in the first trimester maternal serum. In the first trimester, women with twin pregnancies had higher serum concentrations of the anti-angiogenic factor sFlt-1 than that with singleton pregnancies (3924 ± 250 versus 2426 ± 162 pg/ml, respectively; P < 0.001). Maternal serum PlGF concentrations were lower in singleton pregnancies than those in twin pregnancies (37 ± 3.7 versus 59 ± 5.6, respectively; P < 0.001). Serum concentrations of sFlt-1 were higher in twin pregnancies conceived by ART than those in spontaneous twin pregnancies (4313 ± 389 versus 3522 ± 300 pg/ml, respectively; P < 0.05). No differences between groups were observed for sEng. In the first trimester, twin pregnancies conceived using ART showed a heightened anti-angiogenic status that could explain the increased risk of PE in these cases.
    Full-text · Article · Nov 2011 · Human Reproduction
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