Selective serotonin-reuptake inhibitors and persistent pulmonary hypertension of the newborn

ArticleinNew England Journal of Medicine 354(20):2188-90; author reply 2188-90 · June 2006with2 Reads
Impact Factor: 55.87 · Source: PubMed

    Abstract

    ABSTRACT Background Persistent pulmonary,hypertension of the newborn,(PPHN) is associated with sub- stantial infant mortality and morbidity. A previous cohort study suggested a pos- sible association between maternal use of the selective serotonin-reuptake inhibitor (SSRI) fluoxetine late in the third trimester of pregnancy and the risk of PPHN in the infant. Weperformed,a case–control study to assess whether PPHN is associated with exposure to SSRIs during late pregnancy. Methods