Article

Contagious Equine Metritis: A review

Department of Reproduction, School of Veterinary Medicine, University of California, Davis, USA.
Theriogenology (Impact Factor: 1.8). 04/1979; 11(3):209-16. DOI: 10.1016/0093-691X(79)90029-3
Source: PubMed

ABSTRACT

Contagious Equine Metritis (CEM) is a highly contagious venereal disease of horses caused by a fastidious, Gram-negative coccobacillus which grows best on chocolate agar under microaerophilic conditions (5-10% CO2). Clinically, the disease is characterized by a copious watery-to-mucopurulent, vaginal discharge two to ten days after breeding by an infected stallion (11, 13). Shortened estrous cycle lengths are common and may be the only indication of endometritis in some instances (7). Inapparent carriers of the disease in both the mare and stallion make control of the disease more difficult. Outbreaks of CEM have been reported in England, Ireland, France, Australia and the United States. The current information concerning CEM is reviewed.

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    • "The methods used should provide useful background for development of vaccines for gonorrhea and, perhaps, for the many similar species-specific gram-negative chronic venereal infections with asymptomatic carrier states in other animals. The recently discovered contagious equine metritis caused by a hemophilus-like microaerophilic coccobacillus (Eaglesome et al., 1979a) 45 is a possible example. The second classic venereal disease to be considered is syphilis. "

    Preview · Article · Jan 1981 · American Journal Of Pathology
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    ABSTRACT: Examination of recently isolated cultures of three strains of Contagious Equine Metritis Organism grown on specially formulated, serum-free, clear typing medium revealed the presence of numerous colonial opacity variants. These colonies were prepared by a number of fixation and staining techniques and examined by scanning and transmission electron microscopy. Opaque and transparent phenotypes produced copious amounts of extracellular material compared with intermediate-opacity phenotypes which produced little or none. Also unique to intermediate colonies were numerous thin intercellular strands, which may represent pili or polymers of extracellular material. The presence of an unusual fibrillar layer (with similar electron density to the extracellular material) on the outer leaf of the outer membrane also was confirmed. A number of other ultrastructural features also were noted, including an epilayer, a thin nonmembranous layer which covered colonies and adjacent agar.
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