Renal transplant patient with polyoma virus bladder infection and subsequent polyoma virus nephropathy

Department of Pathology, Mount Sinai School of Medicine, New York 10029, USA.
International Journal of Urology (Impact Factor: 2.41). 05/2006; 13(4):439-41. DOI: 10.1111/j.1442-2042.2006.01337.x
Source: PubMed


Polyoma virus nephropathy (PVN) is a significant cause of renal allograft dysfunction in transplant patients. A 58-year-old male received a cadaveric renal transplant and 12 weeks later presented with fever, diarrhea, and dysuria. He was diagnosed with a polyoma virus infection of the bladder by a transurethral bladder biopsy. One year post-transplant, he presented with renal allograft dysfunction and was diagnosed by biopsy with PVN of the non-native kidney. The diagnosis of a polyoma virus infection was confirmed by immunoreactivity to the polyoma T-antigen. We suggest that polyoma virus infection of the bladder be included in the differential diagnosis of urinary dysfunction in post-transplant patients, as such infections might be an under-recognized comorbidity in individuals with PVN.

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