An optically driven pump for microfluidics

Physics and Astronomy, University of Glasgow, Glasgow, UK.
Lab on a Chip (Impact Factor: 6.12). 07/2006; 6(6):735-9. DOI: 10.1039/b601886f
Source: PubMed


We demonstrate a method for generating flow within a microfluidic channel using an optically driven pump. The pump consists of two counter rotating birefringent vaterite particles trapped within a microfluidic channel and driven using optical tweezers. The transfer of spin angular momentum from a circularly polarised laser beam rotates the particles at up to 10 Hz. We show that the pump is able to displace fluid in microchannels, with flow rates of up to 200 microm(3) s(-1) (200 fL s(-1)). The direction of fluid pumping can be reversed by altering the sense of the rotation of the vaterite beads. We also incorporate a novel optical sensing method, based upon an additional probe particle, trapped within separate optical tweezers, enabling us to map the magnitude and direction of fluid flow within the channel. The techniques described in the paper have potential to be extended to drive an integrated lab-on-chip device, where pumping, flow measurement and optical sensing could all be achieved by structuring a single laser beam.

Download full-text


Available from: Miles John Padgett
  • Source
    • "Moreover, this technique does not require controlling the laser power of the trapping beam or flow velocity[20],[26]. Given its convenient operation and easy integration into a microfluidic platform, this technique has considerable direct significance in the fields of biotechnology and nanotechnology, such as in cell diagnosis, nanomotors, micropumps , and microfluidic mixing in a localized environment[23],[24]. "

    Full-text · Article · Jan 2016 · IEEE Photonics Journal
  • Source
    • "Some other techniques use electrically induced fluid flow like electroosmosis, AC electroosmosis [3] [4] [5], and electrowetting [6]. Mechanical techniques have also been reported, such as the optical tweezer driven counterrotating particles pump [7], mechanical disc pump [8], and gravitational gradient fluid flow [9]. "
    [Show abstract] [Hide abstract]
    ABSTRACT: This study presents a technique to manipulate particles in microchannels using arrays of individually excitable electrodes. These electrodes were energized sequentially to form a non-uniform electric field that moved along the microchannel. The non-uniform electric field caused dielectrophoresis to make polarized particles move. This technique was demonstrated using viable yeast cells in a suspending medium with different conductivities. The viable yeast cells experienced positive dielectrophoresis and negative dielectrophoresis in medium conductivity of 21.5 μS/cm and 966 μS/cm respectively. The experimental results indicate that the cells can be transported in either condition using the proposed technique. Singapore-MIT Alliance (SMA)
    Full-text · Article · Jan 2007
  • Source
    • "Reprinted with permission (Leach et al. 2006) Microfluid Nanofluid (2008) "
    [Show abstract] [Hide abstract]
    ABSTRACT: Optofluidic technology is believed to provide a breakthrough for the currently underlying problems in microfluidics and photonics/optics by complementary integration of fluidics and photonics. The key aspect of the optofluidics technology is based on the use of fluidics for tuning the optical properties and addressing various functional materials inside of microfluidic channels which have build-in photonic structures. Through the optofluidic integrations, fluidics enhances the controllability and tunability of optical systems. In particular, colloidal dispersion gives novel properties such as photonic band-gaps and enhanced Raman spectrum that conventional optofluidic devices cannot exhibit. In this paper, the state of the art of the colloidal dispersions is reviewed especially for optofluidic applications. From isolated singlet colloidal particles to colloidal clusters, their self-organized assemblies lead to optical manipulation of the photonic/optical properties and responses. Finally, we will discuss the prospects of the integrated optofluidics technology based on colloidal systems.
    Full-text · Article · Jan 2007 · Microfluidics and Nanofluidics
Show more