Exciting fluctuations: monitoring competence induction dynamics at the single-cell level

Harvard University, Cambridge, Massachusetts, United States
Molecular Systems Biology (Impact Factor: 10.87). 02/2006; 2(1):2006.0025. DOI: 10.1038/msb4100064
Source: PubMed
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    • "Phenotypic heterogeneity is a widespread phenomenon in the bacterial realm. Examples of phenotypic heterogeneity include lactose utilization in Escherichia coli [19], competence development in Bacillus subtilis [20] [21] [22], sporulation in Bacillus subtilis [23] [24] [25] [26], and persistence in Mycobacterium tuberculosis [27] [28] [29]. The potential function of phenotypic heterogeneity with stochastic phenotype switching is generally understood to be a bet-hedging strategy [7] [12] [30] [31], a term originating from finance. "
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