A genetic basis for human susceptibility to West Nile virus

ArticleinTrends in Microbiology 14(7):287-9 · August 2006with7 Reads
Impact Factor: 9.19 · DOI: 10.1016/j.tim.2006.05.004 · Source: PubMed

    Abstract

    West Nile virus (WNV) infects thousands of humans annually and causes a spectrum of disease ranging from an acute febrile illness to lethal encephalitis. A new study suggests a link between CCR5Delta32 (a common mutant allele of the chemokine and HIV receptor CCR5) and fatal WNV infection. The study highlights a possible risk in targeting this receptor for the prevention and/or treatment of infectious diseases.