Article

Coffee, tea and caffeine consumption in relation to osteoporotic fracture risk in a cohort of Swedish women

Department of Toxicology, National Food Administration, P. O. Box 622, 75126 Uppsala, Sweden.
Osteoporosis International (Impact Factor: 4.17). 06/2006; 17(7):1055-64. DOI: 10.1007/s00198-006-0109-y
Source: PubMed

ABSTRACT

Consumption of coffee and tea, and total intake of caffeine has been claimed to be associated with osteoporotic fracture risk. However, results of earlier studies lack consistency.
We examined this relation in a cohort of 31,527 Swedish women aged 40-76 years at baseline in 1988. The consumption of coffee, caffeinated tea and the intake of caffeine were estimated from a self-administered food frequency questionnaire (FFQ). Multivariate-adjusted hazards ratios (HRs) of fractures with 95% confidence intervals (95% CIs) were estimated by Cox proportional hazards models.
During a mean follow-up of 10.3 years, we observed 3,279 cases with osteoporotic fractures. The highest (>330 mg/day) compared with the lowest (<200 mg/day) quintile of caffeine intake was associated with a modestly increased risk of fracture: HR 1.20 (95% CI: 1.07-1.35). A high coffee consumption significantly increased the risk of fracture (p for trend 0.002), whereas tea drinking was not associated with risk. The increased risk of fracture with both a high caffeine intake and coffee consumption was confined to women with a low calcium intake (<700 mg/day): HR 1.33 (95% CI: 1.07-1.65) with > or =4 cups (600 ml)/day of coffee compared to <1 cup (150 ml)/day. The same comparison but risk estimated for women with a high propensity for fractures (> or =2 fracture types) revealed a HR of 1.88 (95% CI: 1.17-3.00).
In conclusion, our results indicate that a daily intake of 330 mg of caffeine, equivalent to 4 cups (600 ml) of coffee, or more may be associated with a modestly increased risk of osteoporotic fractures, especially in women with a low intake of calcium.

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    • "In prior studies showing a positive association, risk of osteoporosis (osteoporosis-induced fracture) was significantly increased when more than 4 cups/day of coffee (330 mg of caffeine, equivalent to 600 ml of coffee) was consumed (relative risk [RR], 1.2–1.9) [11, 14, 30]. This is quite a significant amount of coffee considering that the average amount of coffee consumption is merely 0.7 cup/day in the Korean population [29]. "
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    Full-text · Article · Jan 2016 · PLoS ONE
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    • "Recently, studies revealed possible associations between coffee consumption and OP in postmenopausal women [8] [9]. However, no associations between coffee consumption and outcome in postmenopausal women have been reported [10] [11] [12] [13]. No consistent conclusion has been drawn from studies that investigated the associations. "
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    ABSTRACT: Background: This study was aimed at estimating the associations between coffee intake and osteoporosis (OP) in Chinese postmenopausal women. Methods: We conducted a large-scale, community-based, cross-sectional study to investigate the associations by using self-report questionnaire to access frequency of coffee intake. The total of 1817 participants was available to data analysis in this study. Multiple regression models controlling for confounding factors to include frequency of coffee intake variable were performed to investigate the relationships for OP. Results: Positive correlations between frequency of meat food intake and T-score were reported (β = 0.216, P value < 0.001). Multiple regression analysis indicated that the frequency of meat food intake was significantly associated with OP (P < 0.05 for model 1 and model 2). The postmenopausal women with high frequency of meat food intake had a lower prevalence of OP. Conclusion: The findings indicated that frequency of coffee intake was independently and significantly associated with OP. The prevalence of OP was more frequent in Chinese postmenopausal women not preferring coffee habits.
    Full-text · Article · Sep 2015 · International Journal of Clinical and Experimental Medicine
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    • "Estimated average Korean coffee consumption is about 1.28 cups per day, which is the equivalent of approximately 180 mg of caffeine daily.3) Recently, several investigators have reported that the consumption of coffee is associated with low bone density and osteoporotic fracture.4) Osteoporotic fractures are associated with morbidity and mortality, increasing health costs, and decreased quality of life. "
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