Striatal Functional Alteration in Adolescents Characterized by Early Childhood Behavioral Inhibition

Department of Psychiatry, Virginia Commonwealth University, Ричмонд, Virginia, United States
The Journal of Neuroscience : The Official Journal of the Society for Neuroscience (Impact Factor: 6.34). 07/2006; 26(24):6399-405. DOI: 10.1523/JNEUROSCI.0666-06.2006
Source: PubMed


The temperamental style of behavioral inhibition has been characterized by exaggerated behavioral and neural responses to cues signaling threat. Virtually no work, however, has addressed whether behavioral inhibition may also confer heightened brain activation in response to positively valenced incentives. We used event-related functional MRI (fMRI) and a monetary incentive delay task to examine whether the neural response to incentives is also greater in adolescents characterized as behaviorally inhibited early in life compared with those characterized as non-inhibited. Whereas task performance did not differ between groups, fMRI revealed greater striatal activation to incentives in behaviorally inhibited adolescents than in non-inhibited adolescents. This was regardless of whether the incentive was an anticipated gain or loss. Alteration in neural systems underlying behavior modulated by both negative and positive contingencies may represent a correlate of behavioral inhibition that also underlies vulnerability to various forms of developmental psychopathology.

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    • "In addition, associations between insula volume and similar temperamental traits such as shyness have been reported (Yang et al., 2013). Although not initially hypothesized, group differences in amygdala–striatal iFC are consistent with previous task-based studies showing altered striatal function in behaviorally inhibited adolescents (Bar-Haim et al., 2009; Guyer et al., 2006; Helfinstein et al., 2011) and adolescents with an anxiety disorder (Guyer et al., 2012). In the present work, adults characterized with BI in childhood exhibited negative iFC of the striatum with both the left BLA and CMA, while the non-BI group showed no significant iFC in these circuits, a finding consistent with previous work with anxious adolescents (Roy et al., 2013). "
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    • "In addition to mirroring previous findings that adolescents with a trait levels of social reticence (i.e. behavioral inhibition) show greater sensitivity to reward (Guyer et al., 2006b), our findings add greater specificity to our understanding of how these social characteristics influence reward processing. That is, as boys with low levels of sociability (i.e. "
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    • "First, it should be noted that a growing body of work has begun to relate reward processing to various syndromes characterized by externalizing behaviors (e.g., ADHD and risk for substance use; Cservenka & Nagel, 2012; Rubia et al., 2009; Scheres, Milham, Knutson, & Castellanos, 2007). Furthermore, hypersensitivity to rewards in the striatum has been observed in adolescents with a temperament of behavioral inhibition (Guyer et al., 2006) as well as in adolescent social phobia (Guyer, 2012). However, we sought to understand individual differences in decision-making and reward processing in typically developing adolescents. "
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