Deep brain stimulation

Department of Brain and Cognitive Sciences, University of Rochester, Rochester, New York, United States
Annual Review of Neuroscience (Impact Factor: 19.32). 02/2006; 29(1):229-57. DOI: 10.1146/annurev.neuro.29.051605.112824
Source: PubMed


Deep brain stimulation (DBS) has provided remarkable benefits for people with a variety of neurologic conditions. Stimulation of the ventral intermediate nucleus of the thalamus can dramatically relieve tremor associated with essential tremor or Parkinson disease (PD). Similarly, stimulation of the subthalamic nucleus or the internal segment of the globus pallidus can substantially reduce bradykinesia, rigidity, tremor, and gait difficulties in people with PD. Multiple groups are attempting to extend this mode of treatment to other conditions. Yet, the precise mechanism of action of DBS remains uncertain. Such studies have importance that extends beyond clinical therapeutics. Investigations of the mechanisms of action of DBS have the potential to clarify fundamental issues such as the functional anatomy of selected brain circuits and the relationship between activity in those circuits and behavior. Although we review relevant clinical issues, we emphasize the importance of current and future investigations on these topics.

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Available from: Jonathan W Mink
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    • "For dozens of years, neural electrodes that enabled the selective stimulation and recording of multiple independent neurons of the central neural system (CNS) or the peripheral neural system (PNS) have been expected to provide enhanced functioning of neural prosthetic devices. Some good examples of this are the treatment of spinal cord injuries and the subsequent rehabilitation [1] [2] [3], urinary incontinence [4] [5] [6], cochlear implants [7] [8] [9] [10], and deep brain stimulation (DBS) [11]. Furthermore, neurophysiologists use neural electrodes to investigate the physiological functions of the brain, such as brain-computer interfaces and brain-machine interfaces, by the practice of stimulating neurons and recording their responses [12] [13] [14]. "
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    • "Deep brain stimulation (DBS) has been shown to be effective in the treatment of movement disorders, such as Parkinson's disease and tremor (Kleiner-Fisman et al. 2006; Perlmutter & Mink, 2006). It has also been used in conditions as diverse as chronic pain and Tourette's syndrome (Bittar et al. 2005; Steeves et al. 2012). "

    Full-text · Conference Paper · May 2015
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    • "Numerous efforts have been made to understand the brain network and develop treatments for its disorders, as schizophrenia, Parkinson, Alzheimer, depression and addiction [1]. Advances in microsystem technology allowed the development of micrometer sized devices that access deep areas of the brain in order to understand neurophysiological processes and restore central nervous system's lost functionalities [2]. "
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