Clinical Experiences of Cardiac Myxoma

Yonsei University, Sŏul, Seoul, South Korea
Yonsei Medical Journal (Impact Factor: 1.29). 07/2006; 47(3):367-71. DOI: 10.3349/ymj.2006.47.3.367
Source: PubMed


Although cardiac myxoma is rare, it is the most common primary cardiac tumor. Seventy-four cases of cardiac myxoma that were surgically treated in our center between August 1980 and February 2005 were retrospectively reviewed. The mean patient age was 50.4 +/- 15.0 (range 7-80) years, and 53 patients (71.6%) were female. The most common preoperative symptom, occurring in 44 patients, was dyspnea. The interval from onset of symptoms to surgery was 9 months. Seventy cases were located in the left atrium, 3 in the right atrium and 1 in the right ventricle. The myxoma in the right ventricle could not be resected completely, due to severe infiltration. Cardiopulmonary bypass and aortic cross clamp times were 100.4 +/- 37.1 and 64.8 +/- 29.8 minutes, respectively. There were no hospital deaths, and 7 patients suffered from postoperative complications including atrial fibrillation in 2 cases. During the follow up period (mean 105.7 +/- 73.6 months), there was no tumor recurrence and 6 late deaths that were not related to the underlying tumor. There was no evidence of tumor growth in the cases with incomplete resection during the 14-month follow-up. In conclusion, in this study there was no recurrence of tumors after complete resection and surgical resection is considered to be the curative method of treatment for cardiac myxoma.

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Available from: Byung-Chul Chang
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    • "What are considered constitutional symptoms (fever, weakness, arthralgia) occurred in 27.7 % of the patients, which corresponded to that in previous reports (from 5 % to 74 %) (Gabe et al., 2002;Meyns et al., 1993). As in previous studies (Yu et al., 2006;Perek et al., 2011), the majority of myxomas located in the left atrium, followed by the right atrium and then the ventricles. It is reported that cardiac myxoma exhibits rapid growth, and most patients show advanced symptoms at the time of surgery (Bhan et al., 1998). "
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    ABSTRACT: and aim: Myxoma is the most common type of primary cardiac neoplasm, but the clinical characteristics and long term outcome are less known in the elderly in China. Methods: We analyzed medical records of 112 consecutive patients who underwent operative resection of cardiac myxoma between December 1988 and December 2010 in our hospital. Their data were retrospectively analyzed and the difference between two age groups (< 60 years, n = 87 and ≥ 60 years, n = 25) was compared. Results: The mean age of 112 patients was 48.8 ± 12.5 (range 13 ~ 75) years, and 66 patients (58.9 %) were female. The interval from onset of symptoms to diagnosis was 12 months and the most common presenting symptoms were chest distress (66 patients 58.9 %), followed by palpitations (55 patients, 49.1 %) and dyspnea (47 patients, 42.0 %). Mitral valve diastolic murmur was heard in 67 (59.1 %) patients. The tumor was located in the left atrium in 96 (85.8 %) patients. There were no in-hospital death. During follow-up ranged between one and twenty-one (7.3 ± 5.3) years, there was no malignancy. Myxoma recurred in 3 (2.7 %) patients and deaths occurred in 5 (4.5 %) patients. The 5 and 15 years survival was 97.8 % and 89.5 %, respectively. To compare with the younger patients, the elderly have higher ratios of concomitant hypertension, fewer complaints of dyspnea and chest distress (p < 0.05). Conclusion: The elderly have lower complaints of dyspnea and chest distress, surgical treatment is associated with low long-term mortality and recurrence rate even in the elder patients.
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    • "Depending on the type and location of the tumor, symptoms will vary. Intracardiac tumors which are myxomatous may be pedunculated and mobile, and may swing wildly around the affected atria, potentially bouncing off the interior walls and inciting atrial fibrillation by this contact (Vermeulen et al., 2009; Yu et al., 2006). The treatment for these tumors is predominantly surgical, and reasonable success has been obtained in this manner (Chuaratanaphong et al., 1995; Ipek et al., 2005).Cardiac rhabdomyomas are a hallmark of tuberous sclerosis, and their natural history is that they recede from the time of birth onward. "

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    • "Myxoma is commonly classified into simple (or sporadic) cardiac myxoma and complicated cardiac myxoma. The latter includes myxoma complex, familial myxoma and myxoma from multicenters , and represents about 7% of all cardiac myxo- mas [1] . Sporadic cardiac myxoma is usually found in middle-aged women, most in the left atrium (LA) as a solitary tumor, at a recurrence rate of 1%-3%. "
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    ABSTRACT: We report a case of myxoma with multiple recurrences in both the atrium and ventricle in a 26-year-old woman five years after the surgical removal of left atrial myxoma. Her 52-year-old mother had a similar medical history. To our knowledge, this was the first familial case who suffered multifocal cardiac myxoma recurrences without any sign of the myxoma complex. Based on our understanding of the mechanism of recurrence, the approaches to prevent the recurrence, and markers to predict recurrence, we propose that multifocal recurrences, as reported herein, may result from a combination of familial predisposition and multifocal onset. The bi-atrial surgical approach and transesophageal echocardiography are preferred for patients with recurrent cardiac myxomas, especially for those with multiple recurrences and familial myxoma. Immunological and genetic screenings may help to identify family members at risk for developing this disease.
    Full-text · Article · Sep 2011
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