Metastatic adenocarcinoma of prostate in a healing sternotomy site
Division of Urology and Renal Transplantation, Oregon Health and Science University, Portland, Oregon, USA.Urology (Impact Factor: 2.19). 08/2006; 68(1):204.e13-5. DOI: 10.1016/j.urology.2006.01.081
Metastatic prostate cancer has a strong predilection for osseous sites, where the disease spreads in 80% of advanced cases. The molecular mechanisms involved in prostate cancer establishment in bone are largely unknown; however, local tissue factors, including those involved in wound healing, have been suggested to play a critical role. We present a case of tumor explosion in a median sternotomy wound after local prostate cancer therapy. This case highlights that novel therapeutic interventions that disrupt the apparent synergistic relationship between tumor cells and the pro-tumorigenic microenvironment may hold great promise in constraining the proliferation of prostate cancer metastases.
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